有丝分裂纺锤体：用生物光剑照亮纺锤体定位。

Mitotic Spindle: Illuminating Spindle Positioning with a Biological Lightsaber.

机构信息

Department of Microbiology and Cell Biology (MCB), Indian Institute of Science (IISc), Bangalore, India.

出版信息

Curr Biol. 2018 Nov 19;28(22):R1308-R1310. doi: 10.1016/j.cub.2018.09.047.

DOI:10.1016/j.cub.2018.09.047

Abstract

In metazoans, positioning of the mitotic spindle is controlled by the microtubule-dependent motor protein dynein, which associates with the cell cortex. Using optogenetic tools, two new studies examine how the levels and activity of dynein are regulated at the cortex to ensure proper positioning of the mitotic spindle.

摘要

在后生动物中，有丝分裂纺锤体的定位由微管依赖性马达蛋白 dynein 控制，dynein 与细胞皮层结合。使用光遗传学工具，两项新的研究检查了皮层中 dynein 的水平和活性如何受到调节，以确保有丝分裂纺锤体的正确定位。