Division of Clinical Psychological Intervention, Department of Education and Psychology, Freie Universität Berlin, Schwendenerstraße 27, 14195 Berlin, Germany.
Institute of Medical Psychology, Center for Psychosocial Medicine, Heidelberg University. Bergheimer Straße 20, 69115 Heidelberg, Germany.
Front Neuroendocrinol. 2019 Jan;52:144-155. doi: 10.1016/j.yfrne.2018.11.002. Epub 2018 Nov 17.
Oxytocin affects physiological and psychological functions that are often expressed sex-specifically, suggesting interactions between oxytocin and sex hormones. As female sex hormone concentrations change during the menstrual cycle, oxytocin might fluctuate, too. This systematic review and meta-analysis investigated endogenous oxytocin concentrations across menstrual cycle phases in healthy women. Data from 13 studies (120 women) showed a significant increase of oxytocin concentrations from the early follicular phase to ovulation (g = 0.39 [0.25; 0.53], p < .001) and a significant decrease from ovulation to the mid-luteal phase (g = -0.50 [-0.81; -0.18], p < .001). There were no significant differences between the early follicular and mid-luteal phase (g = -0.19 [-0.70; -0.32], p = .471). These findings contribute to a deeper understanding of differences in normal and abnormal psychobiological processes in women. They highlight the necessity to consider the menstrual cycle phase in studies on oxytocin in women.
催产素影响通常表现出性别特异性的生理和心理功能，提示催产素与性激素之间存在相互作用。由于女性的性激素浓度在月经周期中发生变化，催产素也可能随之波动。本系统评价和荟萃分析调查了健康女性在月经周期各阶段的内源性催产素浓度。来自 13 项研究（120 名女性）的数据显示，催产素浓度从卵泡早期到排卵（g=0.39[0.25；0.53]，p<.001）显著增加，从排卵到黄体中期（g=-0.50[-0.81；-0.18]，p<.001）显著下降。卵泡早期和黄体中期之间没有显著差异（g=-0.19[-0.70；-0.32]，p=0.471）。这些发现有助于更深入地了解女性正常和异常心理生物学过程的差异。它们强调了在女性催产素研究中考虑月经周期阶段的必要性。
