黄腐酚，一种存在于啤酒中的源自啤酒花的类异戊二烯类黄酮，可损害 SW620 结肠癌细胞的线粒体功能。
Xanthohumol, a hop-derived prenylflavonoid present in beer, impairs mitochondrial functionality of SW620 colon cancer cells.
机构信息
a Grupo Multidisciplinar de Oncología Traslacional, Institut Universitari d´Investigació en Ciències de la Salut (IUNICS) , Universitat de les Illes Balears , Palma de Mallorca , Spain Illes Balears.
b Instituto de Investigación Sanitaria de las Islas Baleares (IdISBa) , Hospital Universitario Son Espases , edificio S , Spain Palma de Mallorca Illes Balears.
出版信息
Int J Food Sci Nutr. 2019 Jun;70(4):396-404. doi: 10.1080/09637486.2018.1540558. Epub 2018 Nov 20.
Xanthohumol (XN) is a hop-derived prenylflavonoid and have been reported to exhibit anticancer properties in several types of cancer. It presents a great interest against colon cancer due to high exposure of this compound in this tissue. Metastatic SW620 cell line was treated with doses ranging from 0.001 to 10 µM of XN to assess their effects on cell viability and mitochondrial function. At low concentrations, XN had no effect on assays carried out, but high concentration of XN led to a decrease in cell viability. In addition, at 10 μM XN, it gave rise to an increase in ROS production accompanied by a decrease in OXPHOS complexes and sirtuin 1 protein expression levels. These results suggest that XN could act as a mitocan and impairs mitochondrial function.
黄腐酚（XN）是一种源自啤酒花的类异戊二烯类黄酮，据报道，它在几种类型的癌症中具有抗癌特性。由于这种化合物在结肠组织中高暴露，因此它对结肠癌具有很大的研究兴趣。用 0.001 到 10μM 浓度的 XN 处理转移性 SW620 细胞系，以评估其对细胞活力和线粒体功能的影响。在低浓度下，XN 对进行的测定没有影响，但高浓度的 XN 导致细胞活力下降。此外，在 10μM 的 XN 作用下，它会导致 ROS 产生增加，同时 OXPHOS 复合物和 SIRT1 蛋白表达水平降低。这些结果表明，XN 可能作为一种线粒体破坏剂，损害线粒体功能。
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