Odgaard Marie, Lohse Nicolai, Petersen Alice Juhl, Bæksgaard Lene
a Department of Oncology , Rigshospitalet , Copenhagen , Denmark.
b Department of Medicine , Queen Ingrid´s Hospital , Nuuk , Greenland.
Int J Circumpolar Health. 2018 Dec;77(1):1546069. doi: 10.1080/22423982.2018.1546069.
Oncological treatment of colorectal cancer (CRC) has been available in Greenland since 2004. Treatment is provided by Queen Ingrid´s Hospital (QIH), under supervision from the Department of Oncology, Rigshospitalet, Denmark. The study describes patient characteristics, oncological treatment and survival for the first 8 years of treatment. The study was a registry-based observational study of all patients in Greenland diagnosed with histologically verified CRC from August 2004 to August 2012. Analyses were stratified according to stage and discussed in relation to reported data from patients with CRC in Denmark. 180 patients were included. . Stage I, II, III, and IV comprised 15, 34, 23, and 23%, respectively. 5% presented with unknown stage. A total of 51% received oncological treatment. 79% of patients with Stage III disease received adjuvant chemotherapy, 61% of patients with metastatic CRC received palliative chemotherapy. Five-year survival was 48 and 53% for colon and rectum cancer, respectively. An insignificant trend towards higher survival in men than in women was seen; adjusted hazard ratio for death (women vs men) = 1.46 (95% CI = 0.97-2.19). In conclusion; Stage distribution, provision of oncological treatment and 5-year survival were comparable to patients diagnosed and treated in Denmark.
自2004年起，格陵兰岛便已开展结直肠癌（CRC）的肿瘤治疗。治疗工作由英格丽德女王医院（QIH）在丹麦里格霍斯医院肿瘤学系的监督下进行。该研究描述了治疗头8年的患者特征、肿瘤治疗情况及生存率。这项研究是一项基于登记处的观察性研究，涵盖了2004年8月至2012年8月期间在格陵兰岛被诊断为组织学确诊CRC的所有患者。分析按阶段分层，并与丹麦CRC患者的报告数据进行了讨论。共纳入180例患者。I期、II期、III期和IV期分别占15%、34%、23%和23%。5%的患者分期不明。共有51%的患者接受了肿瘤治疗。III期疾病患者中有79%接受了辅助化疗，转移性CRC患者中有61%接受了姑息化疗。结肠癌和直肠癌的5年生存率分别为48%和53%。观察到男性生存率高于女性的趋势，但无统计学意义；死亡的调整风险比（女性与男性）=1.46（95%CI=0.97-2.19）。总之，分期分布、肿瘤治疗情况及5年生存率与在丹麦诊断和治疗的患者相当。
