Department of Endoscopy, Guizhou Provincial People's Hospital, Zhongshandong Road 83, Guiyang, 550002, China.
Depatment of Cardiology, Wudan People's Hospital, Guiyang, 550002, China.
Lipids Health Dis. 2018 Nov 20;17(1):261. doi: 10.1186/s12944-018-0911-5.
Colon cancer is a malignancy of the large intestine with high mortality and economic burden. Recent studies reveal a new relationship between blood lipids and the risk of cancer. The presents study aims to investigate the combination of serum lipids with cancer antigens as a novel diagnostic marker for colon cancer.
Two hundred of colon cancer patients or healthy subjects were recruited. Serum lipids and cancer antigens such as total cholesterol (TC), high-density lipoprotein (HDL), carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) were measured.
There were significantly lower level of serum TC or HDL, and significantly higher level of serum CEA or CA19-9 in patients than in healthy subjects. Serum TC or HDL in patients with advanced colon cancer was significantly lower than the ones with early stage disease. The level of serum TC or HDL in patients after surgical removal of colon cancer was significantly higher compared to the ones before surgery, but serum CEA or CA19-9 after surgery was significantly reduced in comparison with the ones before surgery. Combined TC, HDL, CEA and CA19-9 as a diagnostic marker for colon cancer had the highest positive predictive rate in comparison with individual, two or three of the parameters.
The combination of serum TC, HDL, CEA and CA19-9 can be used as an effective marker for colon cancer, and offers a novel strategy for clinical diagnosis and monitoring the disease.
结肠癌是一种大肠恶性肿瘤，死亡率和经济负担高。最近的研究揭示了血脂与癌症风险之间的新关系。本研究旨在探讨血清脂质与癌症抗原的联合作为结肠癌的一种新的诊断标志物。
招募了 200 例结肠癌患者或健康受试者。测量血清脂质和癌症抗原，如总胆固醇（TC）、高密度脂蛋白（HDL）、癌胚抗原（CEA）和糖类抗原 19-9（CA19-9）。
患者的血清 TC 或 HDL 水平明显较低，CEA 或 CA19-9 水平明显较高。晚期结肠癌患者的血清 TC 或 HDL 水平明显低于早期患者。结肠癌手术后患者的血清 TC 或 HDL 水平明显高于手术前，但手术后的血清 CEA 或 CA19-9 明显低于手术前。与单独、两个或三个参数相比，将 TC、HDL、CEA 和 CA19-9 联合作为结肠癌的诊断标志物具有最高的阳性预测率。
血清 TC、HDL、CEA 和 CA19-9 的联合可作为结肠癌的有效标志物，为临床诊断和疾病监测提供了新策略。
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