Robertson M D, Pedersen C, Hinton P J, Mendis A S J R, Cani P D, Griffin B A
Nutritional Sciences, University of Surrey, Guildford, UK.
Nutritional Sciences, University of Surrey, Guildford, UK.
Nutr Metab Cardiovasc Dis. 2018 Dec;28(12):1296-1303. doi: 10.1016/j.numecd.2018.07.006. Epub 2018 Aug 1.
BACKGROUND & AIMS: Serum lipids and lipoproteins are established biomarkers of cardiovascular disease risk that could be influenced by impaired gut barrier function via effects on the absorption of dietary and biliary cholesterol. The aim of this study was to examine the potential relationship between gut barrier function (gut permeability) and concentration of serum lipids and lipoproteins, in an ancillary analysis of serum samples taken from a previous study.
Serum lipids, lipoproteins and functional gut permeability, as assessed by the percentage of the urinary recovery of Cr-labelled EDTA absorbed within 24 h, were measured in a group of 30 healthy men. Serum lipopolysaccharide, high sensitivity C-reactive protein and interleukin-6 were also measured as markers of low-grade inflammation. The group expressed a 5-fold variation in total gut permeability (1.11-5.03%). Gut permeability was unrelated to the concentration of both serum total and low density lipoprotein (LDL)-cholesterol, but was positively associated with serum high density lipoprotein (HDL)-cholesterol (r = 0.434, P = 0.015). Serum HDL-cholesterol was also positively associated with serum endotoxaemia (r = 0.415, P = 0.023).
The significant association between increased gut permeability and elevated serum HDL-cholesterol is consistent with the role of HDL as an acute phase reactant, and in this situation, potentially dysfunctional lipoprotein. This finding may have negative implications for the putative role of HDL as a cardio-protective lipoprotein.
血清脂质和脂蛋白是已确定的心血管疾病风险生物标志物，肠道屏障功能受损可能通过影响膳食和胆汁胆固醇的吸收来影响它们。本研究的目的是在对先前一项研究采集的血清样本进行辅助分析时，检验肠道屏障功能（肠道通透性）与血清脂质和脂蛋白浓度之间的潜在关系。
对一组30名健康男性测量了血清脂质、脂蛋白以及通过24小时内吸收的铬标记乙二胺四乙酸（Cr-labelled EDTA）尿回收率评估的功能性肠道通透性。还测量了血清脂多糖、高敏C反应蛋白和白细胞介素-6作为低度炎症的标志物。该组的总肠道通透性有5倍的变化（1.11 - 5.03%）。肠道通透性与血清总胆固醇和低密度脂蛋白（LDL）胆固醇的浓度均无关，但与血清高密度脂蛋白（HDL）胆固醇呈正相关（r = 0.434，P = 0.015）。血清HDL胆固醇也与血清内毒素血症呈正相关（r = 0.415，P = 0.023）。
肠道通透性增加与血清HDL胆固醇升高之间的显著关联与HDL作为急性期反应物的作用一致，在这种情况下，可能是功能失调的脂蛋白。这一发现可能对HDL作为心脏保护脂蛋白的假定作用产生负面影响。
