医护人员百日咳血清阳性率：来自突尼斯的横断面研究。

Seroprevalence of pertussis among healthcare workers: A cross-sectional study from Tunisia.

机构信息

University of Tunis El Manar, Children's Hospital of Tunis, Laboratory of Microbiology, UR12ES01, Beb Saadoun, 1007 Tunis, Tunisia.

出版信息

Vaccine. 2019 Jan 3;37(1):109-112. doi: 10.1016/j.vaccine.2018.11.023. Epub 2018 Nov 17.

DOI:10.1016/j.vaccine.2018.11.023

PMID:30459070

Abstract

This cross-sectional study aimed to assess pertussis seroprevalence among healthy healthcare workers (HCW) of the Children's Hospital of Tunis, Tunisia. During the study period, 236 blood samples were obtained to determine HCW exposure to pertussis. Concentrations of immunoglobulin G (IgG) to pertussis toxin (PT) were measured using a commercial enzyme-linked immunosorbent assay. Cut-offs values used were 40 and 100 IU/ml, respectively indicative of an infection within the last year and a current/recent infection. Overall, seropositivity rate was 11.4% (95% CI 7.4-15.5) and 2.5% (95% CI 0.5-4.6) of ELISA results were indicative of a current infection. Seroprevalence was significantly most important in nurses (p = 0.03) and in participants aged 21-31y (p = 0.009). Our study confirmed that pertussis is circulating in hospital settings and affecting Tunisian HCW, in close contact with infants. Therefore, a booster dose of acellular pertussis vaccine needs to be considered.

摘要

这项横断面研究旨在评估突尼斯突尼斯儿童医院健康医护人员（HCW）中百日咳的血清流行率。在研究期间，采集了 236 份血样，以确定 HCW 接触百日咳的情况。使用商业酶联免疫吸附试验（ELISA）测定针对百日咳毒素（PT）的免疫球蛋白 G（IgG）浓度。分别使用 40 和 100 IU/ml 的截断值来指示最近一年内的感染和当前/近期感染。总体而言，血清阳性率为 11.4%（95%CI7.4-15.5），ELISA 结果的 2.5%（95%CI0.5-4.6）提示当前感染。护士中的血清阳性率显著更高（p=0.03），21-31 岁参与者中的血清阳性率也更高（p=0.009）。我们的研究证实，百日咳在医院环境中传播并影响与婴儿密切接触的突尼斯 HCW。因此，需要考虑接种非细胞性百日咳疫苗加强针。