Li Nannan, Wang Qi, Wang Yan, Sun Anji, Lin Yiwei, Jin Ye, Li Xiaobai
Department of Geriatrics Cardiology, First Hospital of China Medical University, Shenyang, China.
Department of Psychiatry, The First Hospital of China Medical University, Shenyang, China.
Front Behav Neurosci. 2018 Nov 6;12:266. doi: 10.3389/fnbeh.2018.00266. eCollection 2018.
In recent years, a burgeoning body of research has revealed links between depression and the gut microbiota, leading to the therapeutic use of probiotics for stress-related disorders. In this study, we explored the potential antidepressant efficacy of a multi-strain probiotics treatment (, , and ) in a chronic mild stress (CMS) mouse model of depression and determined its probable mechanism of action. Our findings revealed that mice subjected to CMS exhibited anxiety- and depressive-like behaviors in the sucrose preference test, elevated plus maze, and forced swim test, along with increased interferon-γ, tumor necrosis factor-α, and indoleamine 2,3-dioxygenase-1 levels in the hippocampus. Moreover, the microbiota distinctly changed from the non-stress group and was characterized by highly diverse bacterial communities associated with significant reductions in species. Probiotics attenuated CMS-induced anxiety- and depressive-like behaviors, significantly increased abundance, and reversed the CMS-induced immune changes in the hippocampus. Thus, the possible mechanism involved in the antidepressant-like activity of probiotics is correlated with species via the gut microbiota-inflammation-brain axis.
近年来，大量新兴研究揭示了抑郁症与肠道微生物群之间的联系，从而促使益生菌被用于治疗与压力相关的疾病。在本研究中，我们在慢性轻度应激（CMS）抑郁小鼠模型中探究了多菌株益生菌治疗（、和）的潜在抗抑郁功效，并确定了其可能的作用机制。我们的研究结果显示，经受CMS的小鼠在蔗糖偏好试验、高架十字迷宫试验和强迫游泳试验中表现出焦虑样和抑郁样行为，同时海马体中干扰素-γ、肿瘤坏死因子-α和吲哚胺2,3-双加氧酶-1水平升高。此外，微生物群与非应激组明显不同，其特征是细菌群落高度多样化，同时物种显著减少。益生菌减轻了CMS诱导的焦虑样和抑郁样行为，显著增加了丰度，并逆转了CMS诱导的海马体免疫变化。因此，益生菌抗抑郁样活性可能涉及的机制是通过肠道微生物群-炎症-脑轴与物种相关。
