Tofani Gabriel S S, Clarke Gerard, Cryan John F
APC Microbiome, University College Cork, Ireland.
Department of Anatomy & Neuroscience, University College Cork, Ireland.
FEBS J. 2025 Mar;292(6):1454-1479. doi: 10.1111/febs.17400. Epub 2025 Jan 22.
Modern habits are becoming more and more disruptive to health. As our days are often filled with circadian disruption and stress exposures, we need to understand how our responses to these external stimuli are shaped and how their mediators can be targeted to promote health. A growing body of research demonstrates the role of the gut microbiota in influencing brain function and behavior. The stress response and circadian rhythms, which are essential to maintaining appropriate responses to the environment, are known to be impacted by the gut microbiota. Gut microbes have been shown to alter the host's response to stress and modulate circadian rhythmicity. Although studies demonstrated strong links between the gut microbiota, circadian rhythms and the stress response, such studies were conducted in an independent manner not conducive to understanding the interface between these factors. Due to the interconnected nature of the stress response and circadian rhythms, in this review we explore how the gut microbiota may play a role in regulating the integration of stress and circadian signals in mammals and the consequences for brain health and disease.
现代生活习惯对健康的破坏作用越来越大。由于我们的日常生活常常充满昼夜节律紊乱和压力暴露，我们需要了解我们对这些外部刺激的反应是如何形成的，以及如何针对其调节因子来促进健康。越来越多的研究表明肠道微生物群在影响大脑功能和行为方面的作用。应激反应和昼夜节律对于维持对环境的适当反应至关重要，已知它们会受到肠道微生物群的影响。肠道微生物已被证明会改变宿主对应激的反应并调节昼夜节律。尽管研究表明肠道微生物群、昼夜节律和应激反应之间存在紧密联系，但这些研究是独立进行的，不利于理解这些因素之间的相互作用。由于应激反应和昼夜节律相互关联的性质，在本综述中，我们探讨了肠道微生物群如何在调节哺乳动物应激和昼夜信号整合中发挥作用以及对大脑健康和疾病的影响。
