Li Jia-Ai, Meng Hong-Mei, Cui Zhi-Tao, Wang Xue, Miao Jing
Department of Neurology, The First Hospital of Jilin University, Changchun, China.
Department of Geriatrics, The First Hospital of Jilin University, Changchun, China.
Front Neurol. 2018 Oct 16;9:865. doi: 10.3389/fneur.2018.00865. eCollection 2018.
Recurrent cerebral infarctions are extremely rare in patients with primary Sjögren syndrome. We report a 66-year-old woman who was admitted to our hospital due to acute cerebral infarction with exacerbation of dysphagia and right-sided hemiplegia as the main symptoms. In the past 3 months, she had developed cerebral infarction twice, even though she had no risk factors for atherosclerosis. She was eventually diagnosed with primary Sjögren syndrome based on a long history of dryness of the eyes and mouth, positive anti-Ro(SSA) antibodies, and the findings of a labial salivary gland biopsy. The response to pulse methylprednisolone therapy after recurrent cerebral infarctions was poor. Thus we consider primary Sjögren syndrome patients with central nervous system involvement should be treated as soon as possible.
复发性脑梗死在原发性干燥综合征患者中极为罕见。我们报告一名66岁女性，因急性脑梗死入院，主要症状为吞咽困难加重和右侧偏瘫。在过去3个月里，她虽无动脉粥样硬化危险因素，却已发生两次脑梗死。最终，基于长期的眼干、口干病史、抗Ro（SSA）抗体阳性以及唇腺活检结果，她被诊断为原发性干燥综合征。复发性脑梗死后给予甲泼尼龙冲击治疗效果不佳。因此，我们认为原发性干燥综合征合并中枢神经系统受累的患者应尽早治疗。
