Cheong Seung-Hyun, Han You-Jin, Choi You-Won, Myung Ki-Bum, Lee Ji-Soo, Choi Hae-Young
Department of Dermatology, School of Medicine, Ewha Womans University, Seoul, Korea.
Ann Dermatol. 2010 Feb;22(1):99-101. doi: 10.5021/ad.2010.22.1.99. Epub 2010 Feb 28.
Sjögren syndrome (SS) is a systemic autoimmune disease that mainly affects the salivary and lacrimal glands. It may exist as a primary condition or in association with other systemic autoimmune diseases. Patients with SS usually complain of persistent dryness of the mouth and eyes and other features, including diverse general symptoms and cutaneous symptoms such as purpura. We report here on a case of 34-year-old woman who presented with purple non-blanching palpable purpura on both lower legs, and these lesions had developed soon after drinking alcohol 2 days previously. She had a 2 year history of repeatedly developing rashes in association with drinking alcohol. The physical examination showed dry eyes and dry mouth. The laboratory tests showed positivity for anti-Ro/SS-A antibody and RF and hyperimmunoglobulinemia. She was diagnosed as suffering with primary SS. Herein we report on a patient with primary SS and this patient initially presented with recurrent purpura in association with alcohol ingestion. Drinking alcohol had played a role as a possible aggravating factor for the cutaneous purpura of this patient with SS.
干燥综合征（SS）是一种主要累及唾液腺和泪腺的系统性自身免疫性疾病。它可以作为原发性疾病存在，也可与其他系统性自身免疫性疾病相关联。SS患者通常主诉口腔和眼部持续干燥以及其他症状，包括各种全身症状和皮肤症状，如紫癜。我们在此报告一例34岁女性患者，其双下肢出现紫色不褪色可触及的紫癜，这些皮疹在2天前饮酒后不久出现。她有2年反复饮酒后出现皮疹的病史。体格检查显示眼干和口干。实验室检查显示抗Ro/SS - A抗体和类风湿因子（RF）阳性以及高免疫球蛋白血症。她被诊断为原发性SS。在此我们报告一例原发性SS患者，该患者最初表现为饮酒后反复出现紫癜。饮酒可能是该SS患者皮肤紫癜的一个加重因素。
