Gupta Kirti, Tewari Manoj Kumar, Salunke Pravin
Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Asian J Neurosurg. 2018 Oct-Dec;13(4):1193-1196. doi: 10.4103/ajns.AJNS_247_17.
We present a rare case of pilocytic astrocytoma (PA) with gangliocytic differentiation arising in the suprasellar/chiasmatic region in a young boy that showed a rapid regrowth after the 1 subtotal resection and "differentiated" into pilomyxoid astrocytoma (PMA) in subsequent recurrences. The clinical course, imaging, and histological features have been described with a review of the literature. While PA is well-circumscribed, biphasic tumors with bipolar piloid cells, those arising in the diencephalic region often contain myxoid stroma, angiocentric pattern, and "intermediate" features between PA and PMA. Examples of PMA "maturing" to PA are also on record; however, PA with gangliocytic component differentiating to PMA has not been described in the literature to the best of our knowledge.
我们报告了一例罕见的小儿鞍上/视交叉区域发生的具有神经节细胞分化的毛细胞型星形细胞瘤（PA），该肿瘤在次全切除后迅速复发，并在随后的复发中“分化”为毛黏液样星形细胞瘤（PMA）。本文描述了其临床病程、影像学和组织学特征，并对相关文献进行了综述。虽然PA是边界清楚的双相性肿瘤，由双极毛细胞样细胞构成，但发生于间脑区域的PA常含有黏液样基质、血管中心模式以及PA和PMA之间的“中间”特征。也有PMA“成熟”为PA的病例记录；然而，据我们所知，文献中尚未描述过具有神经节细胞成分的PA分化为PMA的情况。
