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AD-lico/Healthy Gut™提取物的胃保护和胃动力益处。

Gastroprotective and gastric motility benefits of AD-lico/Healthy Gut™ extract.

作者信息

Sadra Ali, Kweon Hyuck-Se, Huh Sung-Oh, Cho Jaeyoung

机构信息

Department of Pharmacology, College of Medicine, Hallym University, Chuncheon, Gangwon-Do, South Korea.

SynergyBio, Chuncheon, Gangwon-Do, South Korea.

出版信息

Anim Cells Syst (Seoul). 2017 Aug 18;21(4):255-262. doi: 10.1080/19768354.2017.1357660. eCollection 2017.

DOI:10.1080/19768354.2017.1357660
PMID:30460076
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6138315/
Abstract

The aim of this study was to evaluate both the anti- and the gastric-relaxing effects of AD-lico/Healthy Gut™ in rat models. AD-lico/Healthy Gut™ is a specially prepared commercial formulation of extract that is under clinical development for indications of gastrointestinal disease and inflammatory bowel disease. In the current study, the oral administration of AD-lico/Healthy Gut™ significantly reduced mucosal damage from in rats and decreased the expression of the inflammatory markers iNOS and COX-2 in the test cells. AD-lico/Healthy Gut™ also reduced mucosal damage caused by water immersion stress in rats. The accelerated gastric emptying in normal rats was also seen with AD-lico/Healthy Gut™, providing relief in gastric relaxation in the test animals. The special formulation of AD-lico/Healthy Gut™ with reduced levels of component glycyrrhizin also has benefits in minimizing the potential side effects attributed to glycyrrhizin seen with similar extracts in terms of induction of hypokalemia and muscle weakness. The preparation has a relatively high phenolic compound content relative to other methods of preparation and is indicative of lower glycyrrhizin levels. These results suggest that AD-lico/Healthy Gut™ may provide the necessary relief from a number of stomach discomfort issues faced by a large population of people.

摘要

本研究的目的是评估AD-lico/Healthy Gut™在大鼠模型中的抗溃疡和胃舒张作用。AD-lico/Healthy Gut™是一种专门制备的提取物商业制剂，正在针对胃肠道疾病和炎症性肠病进行临床开发。在本研究中，口服AD-lico/Healthy Gut™可显著减轻大鼠的黏膜损伤，并降低测试细胞中炎症标志物诱导型一氧化氮合酶（iNOS）和环氧化酶-2（COX-2）的表达。AD-lico/Healthy Gut™还可减轻大鼠水浸应激引起的黏膜损伤。在正常大鼠中也观察到AD-lico/Healthy Gut™可加速胃排空，缓解测试动物的胃舒张。AD-lico/Healthy Gut™的特殊配方中甘草酸含量降低，在将类似提取物中因甘草酸引起的低钾血症和肌肉无力等潜在副作用降至最低方面也有好处。相对于其他制备方法，该制剂的酚类化合物含量较高，表明甘草酸水平较低。这些结果表明，AD-lico/Healthy Gut™可能为大量人群面临的多种胃部不适问题提供必要的缓解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbd/6138315/e42a3c317a02/TACS_A_1357660_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbd/6138315/772627a0f831/TACS_A_1357660_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbd/6138315/e500f344d81c/TACS_A_1357660_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbd/6138315/cacc64b53796/TACS_A_1357660_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbd/6138315/e42a3c317a02/TACS_A_1357660_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbd/6138315/772627a0f831/TACS_A_1357660_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbd/6138315/e500f344d81c/TACS_A_1357660_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbd/6138315/cacc64b53796/TACS_A_1357660_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbd/6138315/e42a3c317a02/TACS_A_1357660_F0004_C.jpg

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