短采集时间的JPRESS及其在小儿脑肿瘤中的应用。
Short-acquisition-time JPRESS and its application to paediatric brain tumours.
作者信息
Carlin Dominic, Babourina-Brooks Ben, Arvanitis Theodoros N, Wilson Martin, Peet Andrew C
机构信息
Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, West Midlands, UK.
Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham, West Midlands, UK.
出版信息
MAGMA. 2019 Apr;32(2):247-258. doi: 10.1007/s10334-018-0716-6. Epub 2018 Nov 20.
OBJECTIVE
To develop and assess a short-duration JPRESS protocol for detection of overlapping metabolite biomarkers and its application to paediatric brain tumours at 3 Tesla.
MATERIALS AND METHODS
The short-duration protocol (6 min) was optimised and compared for spectral quality to a high-resolution (38 min) JPRESS protocol in a phantom and five healthy volunteers. The 6-min JPRESS was acquired from four paediatric brain tumours and compared with short-TE PRESS.
RESULTS
Metabolite identification between the 6- and 38-min protocols was comparable in phantom and volunteer data. For metabolites with Cramer-Rao lower bounds > 50%, interpretation of JPRESS increased confidence in assignment of lactate, myo-Inositol and scyllo-Inositol. JPRESS also showed promise for the detection of glycine and taurine in paediatric brain tumours when compared to short-TE MRS.
CONCLUSION
A 6-min JPRESS protocol is well tolerated in paediatric brain tumour patients. Visual inspection of a 6-min JPRESS spectrum enables identification of a range of metabolite biomarkers of clinical interest.
目的
开发并评估一种用于检测重叠代谢物生物标志物的短时长 JPRESS 协议，并将其应用于 3 特斯拉场强下的小儿脑肿瘤检测。
材料与方法
在体模和五名健康志愿者中，对短时长协议（6 分钟）进行了优化，并将其光谱质量与高分辨率（38 分钟）的 JPRESS 协议进行比较。从四个小儿脑肿瘤中采集了 6 分钟的 JPRESS 数据，并与短回波时间 PRESS 进行比较。
结果
在体模和志愿者数据中，6 分钟和 38 分钟协议之间的代谢物识别结果具有可比性。对于克莱姆 - 拉奥下界>50%的代谢物，JPRESS 的解读增加了对乳酸、肌醇和 scyllo - 肌醇归属的信心。与短回波时间磁共振波谱相比，JPRESS 在检测小儿脑肿瘤中的甘氨酸和牛磺酸方面也显示出前景。
结论
6 分钟的 JPRESS 协议在小儿脑肿瘤患者中耐受性良好。对 6 分钟 JPRESS 光谱的目视检查能够识别一系列具有临床意义的代谢物生物标志物。
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