Jurkiewicz Dariusz, Zielnik-Jurkiewicz Beata
Klinika Otolaryngologii i Onkologii Laryngologicznej z Klinicznym Oddziałem Chirurgii Czaszkowo-Szczękowo-Twarzowej Wojskowego Instytutu Medycznego w Warszawie.
Oddział Otolaryngologiczny, Szpital Dziecięcy im. prof. dr J. Bogdanowicza w Warszawie.
Otolaryngol Pol. 2018 Oct 31;72(5):1-8. doi: 10.5604/01.3001.0012.7216.
Bacterial lysates stimulate the general immunity of the body in a non-specific way. They act on non-specific defense mechanisms, leading to an increase in type A antibody in mucous membranes, phagocytic activity and INF-ƴ production. They can also stimulate the production of specific antibodies against the bacterial antigens that make up the preparation. The oral immunomodulatory preparations with the best documented clinical efficacy available on the Polish market are Ismigen, Broncho-Vaxom, Ribomunyl and Luivac. They are all lysates of bacterial strains that most often cause respiratory tract infections. In many clinical trials, oral bacterial lysates have been shown to minimize the risk of recurrent respiratory infections in children and adults and reduce the need for antibiotics.
细菌裂解物以非特异性方式刺激机体的整体免疫力。它们作用于非特异性防御机制，导致黏膜中A型抗体增加、吞噬活性增强以及INF-ƴ产生。它们还能刺激针对构成制剂的细菌抗原产生特异性抗体。波兰市场上临床疗效记录最佳的口服免疫调节制剂有依斯米根、支气管疫苗、核糖霉素和鲁伊瓦克。它们都是最常引起呼吸道感染的细菌菌株的裂解物。在许多临床试验中，口服细菌裂解物已被证明可将儿童和成人反复呼吸道感染的风险降至最低，并减少对抗生素的需求。
