Department of Biotechnology, Delhi Technological University (Former Delhi College of Engineering), Delhi, India.
School of Biosciences and Technology, Vellore Institute of Technology University, Vellore, India.
Brief Funct Genomics. 2018 Jul 22;18(4):230-239. doi: 10.1093/bfgp/ely036.
Diabetes and colon cancer are the leading cause of mortality worldwide. According to World Health Organization, the number of patients with diabetes and cancer is going to be elevated by 50% in 2020. However, several flavonoids have been known to be useful in reducing the chance of cancer/diabetes but the hunt of a single biomolecule that can act as therapeutic and preventive molecules for future epidemic continues. In this review, we aim to perform an illustration of all researches done that target molecular signaling using luteolin in cancer/diabetes and predicted target protein using PharmMapper. The search confirms that luteolin can be a remedial molecule for both cancer and diabetes via acting on variety of signaling pathway. Furthermore, we also intend to illustrate/compare the predicted and verified molecular modes of action of luteolin. Fluorescence in situ hybridization analysis confirms the expression of CCND1 in colon cancer while immunofluorescence analysis confirms the CDK4 in diabetes. Finally, an effort has been made to map docking of marker protein-luteolin at a particular site using docking software. This review gives a holistic overview about luteolin as a therapeutic molecule for cancer/diabetes via acting on multiple signaling cascade such as p53, Wnt, eNOS, iNOS, SOD and MMP9, with especial emphasis on the cyclin-CDK pathway. Altogether, the review concludes that luteolin can be a molecule for the therapy of both cancer and diabetes by acting on broad signaling pathway.
糖尿病和结肠癌是全球主要的死亡原因。根据世界卫生组织的数据，2020 年糖尿病和癌症患者的数量将增加 50%。然而，已经有几种类黄酮被证明有助于降低癌症/糖尿病的发病风险，但寻找一种能够作为治疗和预防未来流行疾病的单一生物分子的工作仍在继续。在这篇综述中，我们旨在通过使用叶黄素在癌症/糖尿病中靶向分子信号以及使用 PharmMapper 预测靶蛋白，对所有相关研究进行说明。搜索结果证实，叶黄素可以通过作用于多种信号通路，成为癌症和糖尿病的治疗分子。此外，我们还旨在说明/比较叶黄素的预测和验证的分子作用模式。荧光原位杂交分析证实了 CCND1 在结肠癌中的表达，而免疫荧光分析证实了 CDK4 在糖尿病中的表达。最后，我们使用对接软件尝试对标记蛋白-叶黄素在特定部位的对接进行映射。这篇综述通过作用于多个信号级联，如 p53、Wnt、eNOS、iNOS、SOD 和 MMP9，全面概述了叶黄素作为治疗癌症/糖尿病的分子，特别强调了细胞周期蛋白-CDK 途径。总的来说，该综述得出结论，叶黄素可以通过作用于广泛的信号通路成为治疗癌症和糖尿病的一种分子。
