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在中国无糖尿病的成年人及老年人中,ABSI对胰岛素抵抗的预测能力较差。

ABSI is a poor predictor of insulin resistance in Chinese adults and elderly without diabetes.

作者信息

Wu Kai, He Sen, Zheng Yi, Chen Xiaoping

机构信息

Department of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu, China.

Department of Cardiovascular Medicine, Guangyuan Central Hospital, Guangyuan, China.

出版信息

Arch Endocrinol Metab. 2018 Oct;62(5):523-529. doi: 10.20945/2359-3997000000072.

Abstract

OBJECTIVE

Recently, a new obesity index (A Body Shape Index, ABSI) based on waist circumference (WC) was developed, and high ABSI corresponds to a more central concentration of body volume. It is well known that central obesity is closely linked with insulin resistance (IR). Therefore, our study aimed to examine the discriminatory power of ABSI for IR in Chinese adults and elderly without diabetes.

SUBJECTS AND METHODS

In 2007, a cross-sectional study was made. In this study, 570 individuals without diabetes were available for analysis (male: 56.1%, mean age: 62.3 ± 6.5 years). Insulin resistance was assessed by homeostasis model assessment (HOMA-IR). Areas under the receiver operating characteristic (ROC) curves were determined to identify variables/models that could predict insulin resistance.

RESULTS

ABSI was associated with IR, the cut-off points was 0.0785 m11/6kg-2/3 to identifying IR and the area under the ROC (AUC) curve was 0.618 (95%CI: 0.561-0.675), which was not better than body mass index BMI (AUC = 0.753; 95%CI: 0.706-0.801), WC (AUC = 0.749; 95%CI: 0.700-0.797), and fasting plasma glucose (FPG, AUC = 0.752; 95%CI: 0.705-0.799). Furthermore, combination with ABSI could improve the discriminatory power of other variables for IR. The AUC curve increased from 0.753 to 0.771for BMI, 0.749 to 0.754 for WC, 0.752 to 0.769 for FPG, respectively.

CONCLUSIONS

ABSI is associated with IR in the general Chinese adults and elderly without diabetes, but the discriminatory power for IR is poor. It is recommended that ABSI be used in combination with other variables.

摘要

目的

最近,一种基于腰围(WC)的新型肥胖指数(体型指数,ABSI)被开发出来,高ABSI对应着身体体积更集中于中心部位。众所周知,中心性肥胖与胰岛素抵抗(IR)密切相关。因此,我们的研究旨在探讨ABSI对中国非糖尿病成年人及老年人IR的鉴别能力。

对象与方法

2007年进行了一项横断面研究。在本研究中,570名无糖尿病个体可供分析(男性:56.1%,平均年龄:62.3±6.5岁)。采用稳态模型评估(HOMA-IR)评估胰岛素抵抗。确定受试者工作特征(ROC)曲线下面积,以识别可预测胰岛素抵抗的变量/模型。

结果

ABSI与IR相关,识别IR的切点为0.0785 m11/6kg-2/3,ROC曲线下面积(AUC)为0.618(95%CI:0.561-0.675),不如体重指数BMI(AUC = 0.753;95%CI:0.706-0.801)、腰围(WC,AUC = 0.749;95%CI:0.700-0.797)和空腹血糖(FPG,AUC = 0.752;95%CI:0.705-0.799)。此外,将ABSI与其他指标联合使用可提高其他变量对IR的鉴别能力。BMI的AUC曲线从0.753增加到0.771,WC从0.749增加到由0.754,FPG从0.752增加到0.769。

结论

ABSI与中国非糖尿病成年人及老年人的IR相关,但对IR的鉴别能力较差。建议将ABSI与其他变量联合使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7e7/10118652/6a3bfbd7d137/2359-4292-aem-62-05-0523-gf01.jpg

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