Department of Human Nutrition and Hospitality Management, College of Human Environmental Science, The University of Alabama, Tuscaloosa, AL 35487, USA.
Department of Biological Sciences, College of Arts and Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA.
Molecules. 2018 Nov 19;23(11):3019. doi: 10.3390/molecules23113019.
B-cell lymphoma-extra large (Bcl-xL) is an anti-apoptotic Bcl-2 protein found in the mitochondrial membrane. Bcl-xL is reported to support normal brain development and protects neurons against toxic stimulation during pathological process via its roles in regulation of mitochondrial functions. Despite promising evidence showing neuroprotective properties of Bcl-xL, commonly applied molecular approaches such as genetic manipulation may not be readily applicable for human subjects. Therefore, findings at the bench may be slow to be translated into treatments for disease. Currently, there is no FDA approved application that specifically targets Bcl-xL and treats brain-associated pathology in humans. In this review, we will discuss naturally occurring nutrients that may exhibit regulatory effects on Bcl-xL expression or activity, thus potentially providing affordable, readily-applicable, easy, and safe strategies to protect the brain.
B 细胞淋巴瘤-特大 (Bcl-xL) 是一种存在于线粒体膜中的抗凋亡 Bcl-2 蛋白。据报道，Bcl-xL 通过调节线粒体功能在正常脑发育和保护神经元免受病理过程中的毒性刺激方面发挥作用。尽管有有希望的证据表明 Bcl-xL 具有神经保护特性，但通常应用的分子方法，如基因操作，可能不适用于人体。因此，研究结果可能难以转化为疾病的治疗方法。目前，没有 FDA 批准的专门针对 Bcl-xL 并治疗人类与大脑相关病理的应用。在这篇综述中，我们将讨论可能对 Bcl-xL 表达或活性具有调节作用的天然存在的营养素，从而为保护大脑提供负担得起、易于应用、简便和安全的策略。
