College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425199, Hunan, China.
Institute for Advanced Studies, Wuhan University, 299 Bayi Road, Wuchang District, Wuhan 430072, Hubei, China.
Molecules. 2018 Nov 19;23(11):3022. doi: 10.3390/molecules23113022.
In recent years, there have been extraordinary developments of organophosphine-catalyzed reactions. This includes progress in the area of [4C+X] annulations, which are of particular interest due to their potential for the rapid construction of 5⁻8-membered cyclic products. In this short overview, we summarize the remarkable progress, emphasizing reaction mechanisms and key intermediates involved in the processes. The discussion is classified according to the type of electrophilic reactants that acted as ₄ synthons in the annulation process, in the order of α-alkyl allenoates, γ-alkyl allenoates, α-methyl allene ketones, β'-OAc allenoate, δ-OAc allenoate, activated dienes and cyclobutenones.
近年来，有机膦催化反应取得了非凡的发展。这包括[4C+X]环化反应领域的进展，由于其快速构建 5⁻8 元环产物的潜力，这些反应引起了特别关注。在这个简短的综述中，我们总结了显著的进展，强调了反应机制和过程中涉及的关键中间体。讨论根据在环化过程中作为 4 元合成子的亲电反应物的类型进行分类，顺序为α-烷基丙二烯酸酯、γ-烷基丙二烯酸酯、α-甲基丙二烯酮、β'-OAc 丙二烯酸酯、δ-OAc 丙二烯酸酯、活化二烯和环丁烯酮。
