Coates R J, Weiss N S, Daling J R, Morris J S, Labbe R F
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Am J Epidemiol. 1988 Sep;128(3):515-23. doi: 10.1093/oxfordjournals.aje.a114999.
A nested case-control study was conducted to assess the relation between serum levels of selenium and retinol and the subsequent risk of cancer. During the years 1972-1984, in northwest Washington State, 156 cases of cancer were identified among members of two employee cohorts from whom specimens had been previously obtained and stored. Two hundred eighty-seven controls were selected from these cohorts and matched to cases on the basis of employer, age, sex, race, and date of blood draw. Selenium and retinol levels were measured by neutron activation and high pressure liquid chromatography, respectively. Information on known cancer risk factors was collected by telephone interviews of subjects and next of kin. Levels of selenium and retinol were unassociated with the incidence of cancer of all sites combined, both overall and within subgroups defined by age, sex, levels of the other micronutrient, time between blood draw and diagnosis, smoking status, and family history of cancer. These findings suggest that neither serum levels of selenium nor those of retinol have an appreciable effect on the risk of cancer.
开展了一项巢式病例对照研究，以评估血清硒和视黄醇水平与后续癌症风险之间的关系。1972年至1984年期间，在华盛顿州西北部，从两个员工队列的成员中确定了156例癌症病例，之前已从这些成员身上采集并储存了样本。从这些队列中选择了287名对照，并根据雇主、年龄、性别、种族和采血日期与病例进行匹配。硒和视黄醇水平分别通过中子活化和高压液相色谱法测量。通过对受试者及其近亲的电话访谈收集了已知癌症风险因素的信息。总体而言，以及在按年龄、性别、其他微量营养素水平、采血与诊断之间的时间、吸烟状况和癌症家族史定义的亚组中，硒和视黄醇水平与所有部位癌症的发病率均无关联。这些发现表明，血清硒水平和视黄醇水平对癌症风险均无明显影响。
