Menkes M S, Comstock G W, Vuilleumier J P, Helsing K J, Rider A A, Brookmeyer R
N Engl J Med. 1986 Nov 13;315(20):1250-4. doi: 10.1056/NEJM198611133152003.
We studied the relation of serum vitamin A (retinol), beta-carotene, vitamin E, and selenium to the risk of lung cancer, using serum that had been collected during a large blood-collection study performed in Washington County, Maryland, in 1974. Levels of the nutrients in serum samples from 99 persons who were subsequently found to have lung cancer (in 1975 to 1983) were compared with levels in 196 controls who were matched for age, sex, race, month of blood donation, and smoking history. A strong inverse association between serum beta-carotene and the risk of squamous-cell carcinoma of the lung was observed (relative odds, 4.30; 95 percent confidence limits, 1.38 and 13.41). Mean (+/- SD) levels of vitamin E were lower among the cases than the controls (10.5 +/- 3.2 vs. 11.9 +/- 4.90 mg per liter), when all histologic types of cancer were considered together. In addition, a linear trend in risk was found (P = 0.04), so that persons with serum levels of vitamin E in the lowest quintile had a 2.5 times higher risk of lung cancer than persons with levels in the highest quintile. These data support an association between low levels of serum vitamin E and the risk of any type of lung cancer and between low levels of serum beta-carotene and the risk of squamous-cell carcinoma of the lung.
我们利用1974年在马里兰州华盛顿县开展的一项大型采血研究中采集的血清，研究了血清维生素A（视黄醇）、β-胡萝卜素、维生素E和硒与肺癌风险之间的关系。将随后（1975年至1983年）被发现患有肺癌的99人的血清样本中的营养素水平，与196名在年龄、性别、种族、献血月份和吸烟史方面相匹配的对照者的水平进行了比较。观察到血清β-胡萝卜素与肺鳞状细胞癌风险之间存在强烈的负相关（相对比值，4.30；95%置信区间，1.38和13.41）。当将所有组织学类型的癌症综合考虑时，病例组的维生素E平均（±标准差）水平低于对照组（10.5±3.2 vs. 11.9±4.90毫克/升）。此外，发现风险呈线性趋势（P = 0.04），因此血清维生素E水平处于最低五分位数的人患肺癌的风险是处于最高五分位数的人的2.5倍。这些数据支持血清维生素E水平低与任何类型肺癌风险之间以及血清β-胡萝卜素水平低与肺鳞状细胞癌风险之间存在关联。
