哥伦比亚血脂异常谱:PURE 研究。
The spectrum of the dyslipidemia in Colombia: The PURE study.
机构信息
Fundación Oftalmológica de Santander (FOSCAL), Floridablanca, Colombia; Universidad Autónoma de Bucaramanga (UNAB), Bucaramanga, Colombia.
Fundación Oftalmológica de Santander (FOSCAL), Floridablanca, Colombia.
出版信息
Int J Cardiol. 2019 Jun 1;284:111-117. doi: 10.1016/j.ijcard.2018.10.090. Epub 2018 Nov 5.
BACKGROUND
Dyslipidemia is a major risk factor for cardiovascular diseases (CVD). Worldwide, a third of ischemic heart disease is due to abnormal cholesterol levels and it is the most common cause of cardiovascular deaths in Colombia. In Colombia, no representative, large-scale study has assessed the prevalence of dyslipidemia. The aim of the present analysis was to identify the magnitude of the problem in Colombia, a middle-income-country with large regional, geographic, and socio-economical differences.
MATERIAL AND METHODS
The sample comprised 6628 individuals aged 35 to 70 years (mean age 50.7 years, 64.1% women) residing in the four Colombian regions.
RESULTS
The overall prevalence of dyslipidemia was 87.7% and was substantially higher among participants older than 50 years, male, rural residents, and those with a lower level of education (66.8%), and with a lower income (66.4%). High non HDL-c was the most common abnormality (75.3%). The values of total cholesterol and non-HDL-cholesterol were higher in areas with the lowest health needs index than in the areas with intermediate and highest health need index, the isolated HDL-c value was much lower.
CONCLUSION
Colombia has a high prevalence of abnormalities of the lipid profile. The causes of the high rates of dyslipidemia were not well define in this study, but were more common in rural and poorer regions and among those with lower socio-economical status. Strategies to tackle the adverse lipid profile to reduce CVD are needed in Colombia, particularly in rural areas and among the areas with the higher health need index.
背景
血脂异常是心血管疾病(CVD)的主要危险因素。在全球范围内,三分之一的缺血性心脏病是由于胆固醇水平异常引起的,它也是哥伦比亚心血管死亡的最常见原因。在哥伦比亚,没有代表性的、大规模的研究评估血脂异常的患病率。本分析的目的是确定血脂异常问题的严重程度,哥伦比亚是一个中高收入国家,存在着巨大的区域、地理和社会经济差异。
材料和方法
该样本包括来自哥伦比亚四个地区的 6628 名年龄在 35 至 70 岁之间的个体(平均年龄为 50.7 岁,64.1%为女性)。
结果
血脂异常的总体患病率为 87.7%,在 50 岁以上、男性、农村居民和受教育程度较低(66.8%)以及收入较低(66.4%)的参与者中明显更高。高非高密度脂蛋白胆固醇是最常见的异常(75.3%)。总胆固醇和非高密度脂蛋白胆固醇的数值在健康需求指数最低的地区高于中等和最高健康需求指数的地区,孤立的高密度脂蛋白胆固醇值要低得多。
结论
哥伦比亚存在血脂谱异常的高患病率。本研究未能明确血脂异常高发生率的原因,但在农村和较贫困地区以及社会经济地位较低的人群中更为常见。哥伦比亚需要采取策略来解决不良的血脂谱问题,以降低 CVD 的风险,特别是在农村地区和健康需求指数较高的地区。