Uhde T W, Stein M B, Post R M
Unit on Anxiety and Affective Disorders, NIMH, Bethesda, MD 20892.
Am J Psychiatry. 1988 Sep;145(9):1104-9. doi: 10.1176/ajp.145.9.1104.
The authors conducted a controlled study of carbamazepine in the treatment of 14 patients with panic disorder. Although there was a statistically significant reduction in symptoms of anxiety on several measures, only one of the patients was judged to have a marked and sustained clinical improvement while taking carbamazepine. Forty percent of the patients had a decrease in frequency of panic attacks during carbamazepine treatment, 50% had an increase, and 10% showed no change. The presence of either EEG abnormalities or prominent psychosensory symptoms did not predict response to carbamazepine. These findings are discussed within the context of an epileptiform model for panic disorder.
作者对卡马西平治疗14例惊恐障碍患者进行了对照研究。尽管在多项测量中焦虑症状有统计学上的显著减轻，但在服用卡马西平期间，只有1例患者被判定有明显且持续的临床改善。40%的患者在卡马西平治疗期间惊恐发作频率降低，50%的患者增加，10%无变化。脑电图异常或明显的心理感觉症状的存在并不能预测对卡马西平的反应。在惊恐障碍的癫痫样模型背景下讨论了这些发现。
