Lab de Endocrinología Molecular, Instituto de Investigaciones Sanitarias de Santiago de Compostela (IDIS), Complejo Hospitalario de Santiago (CHUS), A Coruña, Spain.
CIBER Fisiopatología Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
Sci Rep. 2018 Nov 21;8(1):17155. doi: 10.1038/s41598-018-34840-7.
The incidence of obesity has been increasing dramatically worldwide over the past decades, thus requiring novel and effective therapeutic approaches. OBEX is an oral nutritional supplement composed of antioxidants with antiobesity activity. The effects of OBEX have been tested in vivo and in vitro. In vivo, OBEX reduces weight gain by decreasing adiposity gain and increasing energy expenditure in high fat diet-fed mice through the activation of thermogenesis in brown adipose tissue (BAT) independent of eating behaviors. In vitro analysis with 3T3-F442A cells revealed anti-proliferative and anti-differentiation effects of OBEX. In addition, OBEX induced a clear reduction of the lipid load in mature adipocytes obtained from 3T3-F442A cells. Overall, our findings suggest that OBEX has a protective effect against an obesogenic environment.
在过去几十年中，肥胖的发病率在全球范围内急剧上升，因此需要新的、有效的治疗方法。OBEX 是一种口服营养补充剂，由具有抗肥胖活性的抗氧化剂组成。OBEX 的作用已在体内和体外进行了测试。在体内，OBEX 通过激活棕色脂肪组织 (BAT) 的产热作用，减少高脂肪饮食喂养的小鼠的脂肪量增加和能量消耗，从而减少体重增加，这种作用与饮食行为无关。对 3T3-F442A 细胞的体外分析显示，OBEX 具有抗增殖和抗分化作用。此外，OBEX 可明显减少从 3T3-F442A 细胞获得的成熟脂肪细胞中的脂质负荷。总的来说，我们的研究结果表明，OBEX 对致肥胖环境具有保护作用。
