Zhu Bin, Zhang Lei, Cheng Xiao Ping, Wang Lei, Tian Yue, Li Xi Xi, Liu Ying Ping, Zhao Zhi Gang
Department of Pharmacy, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China,
Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100050, China.
Ther Clin Risk Manag. 2018 Nov 2;14:2183-2188. doi: 10.2147/TCRM.S177265. eCollection 2018.
To examine the association of metabolic syndrome (MetS) with carotid artery stenosis (CAS), especially in menopausal women in China.
A cross-sectional study of menopause women aged ≥40 years were enrolled from the Jidong community of Tangshan City between 2013 and 2014 to examine the association between MetS and CAS. Logistic regression analyses were performed to analyze the association between MetS and the presence of CAS.
A total of 762 menopause women with mean age 59.3±5.6 years were enrolled in our analysis. Of all the people, 111 participants in CAS group (n=159) and 297 participants in no CAS group (n=603) were diagnosed with MetS meantime. Menopausal women with MetS had increased risk of CAS (OR, 2.383; 95% CI, 1.639-3.464), and the association was further verified by adjusting for confounding factors (OR, 1.949; 95% CI, 1.269-2.994). In addition, age, physical activity (never or moderate), body mass index (>24 kg/m), and family income (<3,000 RMB) were independent important factors to CAS development in those with MetS.
MetS is associated with CAS especially in women after menopause.
研究代谢综合征（MetS）与颈动脉狭窄（CAS）之间的关联，尤其是在中国绝经后女性中。
2013年至2014年期间，对唐山市冀东社区年龄≥40岁的绝经后女性进行横断面研究，以探讨MetS与CAS之间的关联。采用逻辑回归分析来分析MetS与CAS存在之间的关联。
共有762名平均年龄为59.3±5.6岁的绝经后女性纳入我们的分析。在所有人群中，CAS组（n = 159）中有111名参与者，无CAS组（n = 603）中有297名参与者同时被诊断为MetS。患有MetS的绝经后女性患CAS的风险增加（比值比，2.383；95%置信区间，1.639 - 3.464），通过调整混杂因素进一步验证了这种关联（比值比，1.949；95%置信区间，1.269 - 2.994）。此外，年龄、体力活动（从不或中等）、体重指数（>24 kg/m²）和家庭收入（<3000元人民币）是患有MetS的人群中CAS发生的独立重要因素。
MetS与CAS相关，尤其是在绝经后女性中。
