Department of Health Information Management, Institute of Medical Information, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100020, China.
Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Chin Med J (Engl). 2018 Oct 5;131(19):2269-2276. doi: 10.4103/0366-6999.241797.
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases with a high prevalence in the general population. The association between NAFLD and cardiovascular disease has been well addressed in previous studies. However, whether NAFLD is associated with carotid artery disease in a community-based Chinese population remained unclear. The aim of this study was to investigate the association between NAFLD and carotid artery disease.
A total of 2612 participants (1091 men and 1521 women) aged 40 years and older from Jidong of Tangshan city (China) were selected for this study. NAFLD was diagnosed by abdominal ultrasonography. The presence of carotid stenosis or plaque was evaluated by carotid artery ultrasonography. Logistic regression was used to analyze the association between NAFLD and carotid artery disease.
Participants with NAFLD have a higher prevalence of carotid stenosis (12.9% vs. 4.6%) and carotid plaque (21.9% vs. 15.0%) than those without NAFLD. After adjusting for age, gender, smoking status, income, physical activity, diabetes, hypertension, triglyceride, waist-hip ratio, and high-density lipoprotein, NAFLD is significantly associated with carotid stenosis (odds ratio [OR]: 2.06, 95% confidence interval [CI]: 1.45-2.91), but the association between NAFLD and carotid plaque is not statistically significant (OR: 1.10, 95% CI: 0.8-1.40).
A significant association between NAFLD and carotid stenosis is found in a Chinese population.
非酒精性脂肪性肝病（NAFLD）是最常见的慢性肝病之一，在普通人群中的患病率很高。先前的研究已经充分探讨了 NAFLD 与心血管疾病之间的关系。然而，NAFLD 是否与中国人群中的颈动脉疾病有关仍不清楚。本研究旨在探讨 NAFLD 与颈动脉疾病之间的关系。
本研究共纳入了来自唐山市冀东地区的 2612 名年龄在 40 岁及以上的参与者（男性 1091 名，女性 1521 名）。通过腹部超声诊断 NAFLD。通过颈动脉超声评估颈动脉狭窄或斑块的存在。采用 logistic 回归分析 NAFLD 与颈动脉疾病之间的关系。
患有 NAFLD 的参与者颈动脉狭窄（12.9%比 4.6%）和颈动脉斑块（21.9%比 15.0%）的患病率均高于无 NAFLD 的参与者。在调整年龄、性别、吸烟状况、收入、体力活动、糖尿病、高血压、甘油三酯、腰臀比和高密度脂蛋白后，NAFLD 与颈动脉狭窄显著相关（比值比[OR]：2.06，95%置信区间[CI]：1.45-2.91），但 NAFLD 与颈动脉斑块之间的关联无统计学意义（OR：1.10，95% CI：0.8-1.40）。
在中国人群中，NAFLD 与颈动脉狭窄之间存在显著关联。
