Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Eur Acad Dermatol Venereol. 2011 Oct;25(10):1182-6. doi: 10.1111/j.1468-3083.2010.03946.x. Epub 2011 Jan 9.
Non-cultured cellular grafting as a surgical procedure is indicated to treat stable vitiligo, refractory to medical treatment, and is gaining wider acceptance among dermatologists.
The aim of this study was to assess the efficacy of non-cultured melanocyte-keratinocyte transplantation (MKT) for the treatment of generalized vitiligo in Iranian patients.
In this clinical trial, a total of 14 vitiligo patches in eight patients were treated; eight patches with non-cultured MKT and six patches dermabraded alone without application of keratinocyte-melanocyte suspension. Repigmentation was compared at about 4 months post-transplantation.
Of the eight lesions treated with non-cultured MKT, four lesions showed 96-100% repigmentation, one lesion 65-95% and three lesions 0-25%. Of the patients who showed excellent results, only one showed a post-inflammatory hyperpigmentation in recipient and control areas. Of the six control lesions, five showed failed repigmentation and one showed post-inflammatory hyperpigmentation.
Non-cultured MKT is an effective method to treat stable vitiligo. Studies on larger series of vitiligo patients are required to confirm its efficacy.
非培养细胞移植物作为一种手术方法，适用于治疗稳定型、对药物治疗无反应的白癜风，且越来越被皮肤科医生所接受。
本研究旨在评估非培养黑素细胞-角质形成细胞移植（MKT）治疗伊朗患者泛发性白癜风的疗效。
在这项临床试验中，共治疗了 8 名患者的 14 个白癜风斑块；8 个斑块采用非培养 MKT 治疗，6 个斑块单独行表皮磨皮术，不应用角质形成细胞-黑素细胞悬液。在移植后约 4 个月比较复色情况。
在接受非培养 MKT 治疗的 8 个病变中，4 个病变的复色率达到 96-100%，1 个病变的复色率为 65-95%，3 个病变的复色率为 0-25%。在表现出良好效果的患者中，只有 1 例在接受区和对照区出现炎症后色素沉着过度。在 6 个对照病变中，5 个病变复色失败，1 个病变出现炎症后色素沉着过度。
非培养 MKT 是治疗稳定型白癜风的有效方法。需要对更大系列的白癜风患者进行研究以确认其疗效。
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