Jafarzadeh Alireza, Mohammad Arash Pour, Goodarzi Azadeh
Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
J Cosmet Dermatol. 2025 Feb;24(2):e16660. doi: 10.1111/jocd.16660. Epub 2024 Nov 7.
The aim of this study is to examine the efficacy and safety of various regenerative medicine treatments, such as cell therapy, platelet-rich plasma (PRP), plasma-poor platelet (PPP), plasma-rich fibrin (PRF), mesenchymal stem cells, stromal vascular fraction (SVF), exosomes, adipose-derived stem cells (ADSC), and stem cell-conditioned media (SC-CM), for treating vitiligo.
We conducted a thorough search of major databases such as PubMed, Scopus, and Web of Science, and selected 48 articles based on specific criteria. We used EndNote X8 and Google Sheets to review and extract data from the articles. After analyzing the studies, we categorized them accordingly.
This systematic review analyzed 48 articles involving 2186 patients with vitiligo to assess the effectiveness of regenerative medicine treatments. Key findings revealed that methods such as autologous non-cultured melanocyte-keratinocyte transplantation and platelet-rich plasma (PRP) injection exhibited significant repigmentation, particularly when combined with modalities like NB-UVB phototherapy and laser treatments. Notably, the autologous melanocyte-keratinocyte transplantation achieved over 50% repigmentation within 9 months, while PRP demonstrated an average repigmentation of 58.7%, especially effective with CO laser treatment. Hair follicle-derived cell transplantation also showed impressive response rates, achieving good to excellent results in up to 93.8% of patients. Side effects were noted in 21 of 28 studies, primarily involving pain, with no serious adverse events reported. The risk of bias assessment indicated that 37.21% of studies were low risk, while 48.84% had high risks overall. These findings suggest that while regenerative medicine holds promise for vitiligo treatment, further clinical trials are necessary to explore additional methods like stromal vascular fraction and exosomes.
We have concluded that regenerative medicine plays an effective role in the treatment of vitiligo lesions. Furthermore, this treatment method is safe and does not cause serious complications. It can be used alone or in combination with other methods for treating vitiligo. To advance the treatment of vitiligo, we recommend conducting clinical trials on the unexplored branches of regenerative medicine.
本研究旨在探讨各种再生医学疗法，如细胞疗法、富血小板血浆（PRP）、少血小板血浆（PPP）、富纤维蛋白血浆（PRF）、间充质干细胞、基质血管成分（SVF）、外泌体、脂肪来源干细胞（ADSC）和干细胞条件培养基（SC-CM）治疗白癜风的疗效和安全性。
我们对PubMed、Scopus和Web of Science等主要数据库进行了全面检索，并根据特定标准筛选出48篇文章。我们使用EndNote X8和谷歌表格对文章进行综述和数据提取。在分析这些研究后，我们进行了相应的分类。
本系统评价分析了48篇涉及2186例白癜风患者的文章，以评估再生医学疗法的有效性。主要发现显示，自体非培养黑素细胞-角质形成细胞移植和富血小板血浆（PRP）注射等方法表现出显著的色素再生，特别是与窄谱中波紫外线（NB-UVB）光疗和激光治疗等方式联合使用时。值得注意的是，自体黑素细胞-角质形成细胞移植在9个月内实现了超过50%的色素再生，而PRP的平均色素再生率为58.7%，对CO2激光治疗尤其有效。毛囊来源细胞移植也显示出令人印象深刻的有效率，在高达93.8%的患者中取得了良好到优异的效果。28项研究中有21项记录了副作用，主要涉及疼痛，未报告严重不良事件。偏倚风险评估表明，37.21%的研究风险较低，而总体上48.84%的研究风险较高。这些发现表明，虽然再生医学对白癜风治疗有前景，但需要进一步的临床试验来探索基质血管成分和外泌体等其他方法。
我们得出结论，再生医学在白癜风皮损治疗中发挥着有效作用。此外，这种治疗方法是安全的，不会引起严重并发症。它可以单独使用或与其他方法联合用于治疗白癜风。为了推进白癜风的治疗，我们建议对再生医学未探索的分支进行临床试验。
