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具有氧化还原反应激活的近红外二区荧光的有机半导体纳米探针，用于体内实时监测药物毒性。

Organic semiconducting nanoprobe with redox-activatable NIR-II fluorescence for in vivo real-time monitoring of drug toxicity.

机构信息

Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications (NUPT), Nanjing 210023, China.

出版信息

Chem Commun (Camb). 2018 Dec 18;55(1):27-30. doi: 10.1039/c8cc08413k.

DOI:10.1039/c8cc08413k
PMID:30465672
Abstract

An activatable organic semiconducting nanoprobe that specifically turns on its second near-infrared window fluorescence upon being exposed to nitric oxide stimuli was developed for in vivo, in situ, real-time and high-spatial-resolution mapping of drug-induced hepatotoxicity.

摘要

开发了一种可激活的有机半导体纳米探针，当暴露于一氧化氮刺激时，它会特异性地开启其二近红外窗口荧光，用于药物诱导肝毒性的体内、原位、实时和高空间分辨率成像。

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