Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan; Department of Ophthalmology, Graduate School of Medical Sciences, Kitasato University, Kanagawa, Japan.
Am J Ophthalmol. 2019 Mar;199:140-149. doi: 10.1016/j.ajo.2018.11.004. Epub 2018 Nov 20.
We previously reported that it was beneficial to apply binomial pointwise linear regression (PLR) to detect 24-2 glaucomatous visual field (VF) progression, compared to mean deviation (MD) trend analysis and permutation analysis of PLR (PoPLR). The purpose of the current study was to validate the usefulness of the binomial PLR method to detect VF progression in the central 10 degrees in glaucoma patients.
Reliability assessment.
A series of 15 VFs (Humphrey Field Analyzer 10-2 SITA-standard) from 97 eyes in 69 primary open-angle glaucoma patients, obtained over 8.5 ± 1.3 years (mean ± SD), were investigated. PLR was performed by regressing the total deviation of all test points on the series of 15 VFs. VF progression was determined from the analyses of VF test points using the binomial test (1-sided, P < .025). The time needed to detect VF progression was also investigated. The results were compared with PoPLR and MD trend analyses.
The binomial PLR was comparable to PoPLR and MD trend analyses in the positive predictive value (0.19 to 0.80), the negative predictive value (0.86 to 1.0), and the false positive rate (0.0 to 0.13) to evaluate glaucomatous VF progression. The time needed to detect VF progression (4.2 ± 1.8 years) was significantly shorter with the binomial PLR method compared with PoPLR and MD trend analysis (P = .04, P = .012, respectively).
The binomial PLR method detected glaucomatous VF progression in the central 10 degrees significantly earlier than PoPLR and MD trend analyses.
我们之前曾报道，与平均偏差（MD）趋势分析和二项式 PLR 的置换分析（PoPLR）相比，应用二项式逐点线性回归（PLR）来检测 24-2 青光眼视野（VF）进展是有益的。本研究的目的是验证二项式 PLR 方法在青光眼患者中央 10 度检测 VF 进展的有用性。
可靠性评估。
对 69 例原发性开角型青光眼患者的 97 只眼中的 15 个连续 VF（Humphrey Field Analyzer 10-2 SITA 标准）进行了研究。在 8.5±1.3 年（均值±标准差）的时间内获得了这些 VF。通过将所有测试点的总偏差回归到 15 个 VF 系列来进行 PLR。通过二项式检验（单侧，P<0.025）对 VF 测试点的分析来确定 VF 进展。还研究了检测 VF 进展所需的时间。将结果与 PoPLR 和 MD 趋势分析进行了比较。
二项式 PLR 在阳性预测值（0.19 至 0.80）、阴性预测值（0.86 至 1.0）和假阳性率（0.0 至 0.13）方面与 PoPLR 和 MD 趋势分析相当，可用于评估青光眼 VF 进展。与 PoPLR 和 MD 趋势分析相比，二项式 PLR 方法检测 VF 进展的时间（4.2±1.8 年）明显缩短（P=0.04，P=0.012）。
二项式 PLR 方法比 PoPLR 和 MD 趋势分析更早地检测到中央 10 度的青光眼 VF 进展。
