Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore.
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore; Duke-NUS Graduate Medical School, Singapore, Republic of Singapore.
Ophthalmology. 2017 Jul;124(7):1065-1071. doi: 10.1016/j.ophtha.2017.02.027. Epub 2017 Mar 31.
To evaluate visual field (VF) progression and rate of glaucomatous VF loss in patients with primary angle-closure glaucoma (PACG) using pointwise linear regression (PLR) trend analysis.
Clinic-based retrospective study.
Primary angle-closure glaucoma patients with 5 or more reliable VF tests and with 5 years or more of follow-up.
Visual field progression was assessed by PROGRESSOR software version 3.7 (Medisoft, Leeds, United Kingdom) and was defined by the presence of at least 2 adjacent testing points located within the same hemifield that showed progression with a change of -1 dB/year or more (P < 0.01) for inner points or -2 dB/year or more (P < 0.01) for edge points. We also performed a logistic regression analysis to determine the variables associated with rapid progression (defined as mean slope of progressing points ≥-1.5 dB/year).
Visual field progression and rate of VF loss.
Of the 1296 patients who were assessed, 398 (30.7%) fulfilled the inclusion criteria of 5 or more VFs and 5 years or more of follow-up. Visual field progression was observed in 63 of 398 eyes (15.8%) according to the PLR criteria. The overall mean rate of VF change for these patients was -0.12±0.51 dB/year over a mean follow-up period of 10.4±3.7 years. There were no significant differences in the age, gender distribution, follow-up duration, or number of VFs between those who showed progression and those who did not (all P > 0.05). The most common sector of VF progression was the superior arcuate area (65%). Rapid progression was found in 36 patients (57%). Multiple logistic regression analysis revealed older age and higher vertical cup-to-disc ratio (VCDR) at presentation as predictors of rapid progression (all P < 0.005) in the progressing group (n = 63).
In patients with PACG being managed in a hospital setting, VF progression was noted in 15.8%, and the overall rate of VF loss was -0.12±0.51 dB/year. The superior arcuate was the most common sector of progression. Older age and higher VCDR at presentation were associated with rapid progression.
使用逐点线性回归（PLR）趋势分析评估原发性闭角型青光眼（PACG）患者的视野（VF）进展和青光眼 VF 损失率。
基于临床的回顾性研究。
具有 5 次或更多可靠 VF 测试且随访时间为 5 年或以上的原发性闭角型青光眼患者。
通过 PROGRESSOR 软件版本 3.7（Medisoft，英国利兹）评估视野进展，通过存在至少 2 个相邻测试点来定义进展，这些测试点位于同一半视野内，且以每年-1 dB 或更多（P < 0.01）的速度变化（对于内点）或每年-2 dB 或更多（P < 0.01）的速度变化（对于边缘点）。我们还进行了逻辑回归分析，以确定与快速进展相关的变量（定义为进展点的平均斜率≥-1.5 dB/年）。
视野进展和 VF 损失率。
在评估的 1296 名患者中，有 398 名（30.7%）符合 5 次以上 VF 和 5 年以上随访的纳入标准。根据 PLR 标准，在 398 只眼中有 63 只（15.8%）观察到视野进展。这些患者的总体平均 VF 变化率为-0.12±0.51 dB/年，平均随访时间为 10.4±3.7 年。在进展组和未进展组之间，年龄、性别分布、随访时间或 VF 数量均无显著差异（均 P > 0.05）。VF 进展最常见的部位是上弓形区（65%）。在 36 名患者（57%）中发现快速进展。多变量逻辑回归分析显示，在进展组（n=63）中，年龄较大和较高的垂直杯盘比（VCDR）是快速进展的预测因素（均 P < 0.005）。
在医院环境中管理的 PACG 患者中，VF 进展发生率为 15.8%，VF 损失的总体率为-0.12±0.51 dB/年。上弓形区是进展最常见的部位。年龄较大和较高的 VCDR 与快速进展相关。
