Lee Jiyun, Park Chan Kee, Park Hae-Young Lopilly
Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
J Clin Med. 2021 Nov 2;10(21):5150. doi: 10.3390/jcm10215150.
To investigate the clinical significance of vessel density (VD) on visual field (VF) progression regarding the severity of glaucoma.
A total of 130 eyes were recruited in this retrospective and longitudinal study. Superficial and deep VDs in circumpapillary and macular regions were measured via ImageJ. The rate of VF progression was defined as the mean deviation (MD) slope (dB/year). Linear regression was used to verify factors affecting deterioration of VF. The eyes with lower superficial VD were further analyzed.
Fifty patients with early glaucoma (EG) (MD > -6 dB) and 52 patients with moderate-to-advanced glaucoma (MAG) (MD ≤ -6 dB) were included. A faster progression rate was found in MAG ( = 0.049). Superficial VD was noticeably related to the VF progression rate in total eyes and in MAG (Both Ps ≤ 0.007, respectively). With patients in the lower half of the superficial VD, the VD was significantly associated with the rate of progression (B, 0.049, = 0.021). This association was independent of the baseline MD and OCT parameters.
Decreased superficial VD might conversely affect the progression of glaucoma even in MAG, which suggests superficial VD could be used as a potential marker to foresee the disease progression even in progressed eyes.
探讨血管密度（VD）对青光眼严重程度的视野（VF）进展的临床意义。
本回顾性纵向研究共纳入130只眼睛。通过ImageJ测量视乳头周围和黄斑区域的浅层和深层VD。VF进展率定义为平均偏差（MD）斜率（dB/年）。采用线性回归分析影响VF恶化的因素。对浅层VD较低的眼睛进行进一步分析。
纳入50例早期青光眼（EG）患者（MD > -6 dB）和52例中重度青光眼（MAG）患者（MD ≤ -6 dB）。发现MAG患者的进展率更快（= 0.049）。浅层VD与全眼及MAG患者的VF进展率显著相关（P值均≤ 0.007）。对于浅层VD处于下半部分的患者，VD与进展率显著相关（B值为0.049，= 0.021）。这种关联独立于基线MD和光学相干断层扫描（OCT）参数。
即使在MAG患者中，浅层VD降低也可能相反地影响青光眼的进展，这表明浅层VD可作为预测疾病进展的潜在标志物，即使在病情进展的眼睛中也是如此。
