Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.
Department of Orthopaedic Surgery, Changzheng hospital, Second Military Medical University, Shanghai 200003, China.
Colloids Surf B Biointerfaces. 2019 Feb 1;174:207-215. doi: 10.1016/j.colsurfb.2018.10.081. Epub 2018 Nov 2.
Polyetheretherketone (PEEK) biomaterial has become increasingly popular in orthopedic applications due to its favorable biocompatibility, biostability, mechanical strength and elastic modulus similar to natural bones. In this research, in order to improve the biological performances of PEEK, tantalum pentoxide (TaO) was incorporated into PEEK to fabricate PEEK/TaO composites (PTC) using a method of cold press-sintering, and surface coarsening of PTC was prepared by sand blasting. The results showed that the TaO particles were uniformly disperse into PEEK, and thermal and mechanical properties of PTC were enhanced with the increase of TaO content. In addition, incorporating TaO into PEEK and surface coarsening could improve surface roughness, hydrophilicity, surface energy and protein absorption of PTC. Furthermore, the adhesion and proliferation as well as osteogenic differentiation of BMSCs on PTC were significantly promoted and regulated by TaO content and surface coarsening. The results indicated that surface coarsening of PTC (PTCS) with high surface roughness, hydrophilicity and surface energy could induce positive cellular responses, showing good cytocompatibility. PTCS might have a great potential as implants for bone repair.
聚醚醚酮（PEEK）生物材料由于其良好的生物相容性、生物稳定性、机械强度和与天然骨骼相似的弹性模量，在骨科应用中越来越受欢迎。在这项研究中，为了提高 PEEK 的生物学性能，采用冷压-烧结的方法将五氧化二钽（TaO）掺入 PEEK 中，制备 PEEK/TaO 复合材料（PTC），并用喷砂的方法对 PTC 进行表面粗化。结果表明，TaO 颗粒均匀地分散在 PEEK 中，随着 TaO 含量的增加，PTC 的热性能和力学性能得到了提高。此外，将 TaO 掺入 PEEK 并进行表面粗化可以提高 PTC 的表面粗糙度、亲水性、表面能和蛋白质吸附能力。进一步的，BMSCs 在 PTC 上的黏附、增殖和成骨分化也明显得到了 TaO 含量和表面粗化的促进和调节。结果表明，具有高表面粗糙度、亲水性和表面能的 PTC 的表面粗化（PTCS）可以诱导积极的细胞反应，表现出良好的细胞相容性。PTCS 有望成为骨修复的植入物。
