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一种作为骨科植入材料的纳米羟基磷灰石/聚醚醚酮生物复合材料的制备、表征及体外成骨细胞功能

Preparation, characterization, and in vitro osteoblast functions of a nano-hydroxyapatite/polyetheretherketone biocomposite as orthopedic implant material.

作者信息

Ma Rui, Tang Songchao, Tan Honglue, Lin Wentao, Wang Yugang, Wei Jie, Zhao Liming, Tang Tingting

机构信息

Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, People's Republic of China.

Key Laboratory for Ultrafine Materials of Ministry of Education and The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, People's Republic of China.

出版信息

Int J Nanomedicine. 2014 Aug 18;9:3949-61. doi: 10.2147/IJN.S67358. eCollection 2014.

DOI:10.2147/IJN.S67358
PMID:25170265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4145828/
Abstract

A bioactive composite was prepared by incorporating 40 wt% nano-hydroxyapatite (nHA) into polyetheretherketone (PEEK) through a process of compounding, injection, and molding. The mechanical and surface properties of the nHA/PEEK composite were characterized, and the in vitro osteoblast functions in the composite were investigated. The mechanical properties (elastic modulus and compressive strength) of the nHA/PEEK composite increased significantly, while the tensile strength decreased slightly as compared with PEEK. Further, the addition of nHA into PEEK increased the surface roughness and hydrophilicity of the nHA/PEEK composite. In cell tests, compared with PEEK and ultra-high-molecular-weight polyethylene, it was found that the nHA/PEEK composite could promote the functions of MC3T3-E1 cells, including cell attachment, spreading, proliferation, alkaline phosphatase activity, calcium nodule formation, and expression of osteogenic differentiation-related genes. Incorporation of nHA into PEEK greatly improved the bioperformance of PEEK. The nHA/PEEK composite might be a promising orthopedic implant material.

摘要

通过复合、注塑和成型工艺，将40重量%的纳米羟基磷灰石（nHA）掺入聚醚醚酮（PEEK）中制备了一种生物活性复合材料。对nHA/PEEK复合材料的力学性能和表面性能进行了表征，并研究了该复合材料在体外的成骨细胞功能。与PEEK相比，nHA/PEEK复合材料的力学性能（弹性模量和抗压强度）显著提高，而拉伸强度略有下降。此外，向PEEK中添加nHA增加了nHA/PEEK复合材料的表面粗糙度和亲水性。在细胞测试中，发现与PEEK和超高分子量聚乙烯相比，nHA/PEEK复合材料能够促进MC3T3-E1细胞的功能，包括细胞附着、铺展、增殖、碱性磷酸酶活性、钙结节形成以及成骨分化相关基因的表达。将nHA掺入PEEK中大大改善了PEEK的生物性能。nHA/PEEK复合材料可能是一种很有前途的骨科植入材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e48/4145828/78443dba051b/ijn-9-3949Fig11.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e48/4145828/78443dba051b/ijn-9-3949Fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e48/4145828/852b420763e3/ijn-9-3949Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e48/4145828/08e40d66dea3/ijn-9-3949Fig2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e48/4145828/4240f7b6e5c6/ijn-9-3949Fig8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e48/4145828/1521e507b7b8/ijn-9-3949Fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e48/4145828/78443dba051b/ijn-9-3949Fig11.jpg

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J Biomed Nanotechnol. 2014 Jun;10(6):1091-104. doi: 10.1166/jbn.2014.1696.
2
Natural and synthetic biodegradable polymers: different scaffolds for cell expansion and tissue formation.天然和合成可生物降解聚合物：用于细胞扩增和组织形成的不同支架。
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3
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4
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6
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6
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8
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