白沙瓦登革热疫情：登革病毒感染的临床特征和实验室标志物。
Dengue Outbreak in Peshawar: Clinical Features and Laboratory Markers of Dengue Virus Infection.
机构信息
Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan.
Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan.
出版信息
J Infect Public Health. 2019 Mar-Apr;12(2):258-262. doi: 10.1016/j.jiph.2018.10.138. Epub 2018 Nov 19.
BACKGROUND
Dengue is a tropical disease caused by dengue virus (DENV). It is one of the most significant arthropod-borne viral infection.
OBJECTIVES
The aim of the current study was to characterize epidemiological, clinical features and laboratory markers of dengue infection during the recent epidemic in Peshawar, KP.
METHODS
During the prospective hospital-based observational study, 2000 dengue suspected cases were serologically examined at Lady Reading Hospital (LRH) Peshawar. Dengue NS1 antigen and Dengue IgG and IgM antibody ELISA tests were conducted for the confirmation of dengue infection. Data regarding the clinical features, platelet count and liver function tests were also recorded for the dengue positive patients.
RESULTS
Out of total samples 415 (21%) cases including 309 (74%) male and 106 (25%) female were detected positive for the dengue infection. In the dengue positive patients, the highest prevalence was observed in the age group of 21-40years with 160 (38%) followed by the age group of 1-20years with 89 (21%) patients. Fever was recorded in 100% of the dengue patients followed by a headache and fatigue in 73% and liver abnormality observed in 70% of the cases. During laboratory examinations IgM antibody was detected in 180 cases, followed by IgG antibody in 87, NS1 antigen in 43, NS1 antigen along with IgG and IgM antibodies in 41 dengue positive cases. Another combine detection of NS1 antigen with IgM antibody, NS1 antigen with IgG antibody and both IgG and IgM antibodies was observed in 21, 21, 22 dengue cases respectively.
CONCLUSION
It was concluded that the dengue infection can be early diagnosed on the basis of described clinical features and with the detection of dengue-specific NS1 antigen along with antibodies such as IgG and IgM.
背景
登革热是由登革病毒（DENV）引起的热带疾病。它是最重要的虫媒病毒感染之一。
目的
本研究旨在描述开伯尔-普赫图赫瓦省白沙瓦最近登革热流行期间的登革热感染的流行病学、临床特征和实验室标志物。
方法
在前瞻性基于医院的观察性研究中，在白沙瓦的 Lady Reading 医院（LRH）对 2000 例疑似登革热病例进行了血清学检查。进行了登革热 NS1 抗原和登革热 IgG 和 IgM 抗体 ELISA 检测，以确认登革热感染。还记录了登革热阳性患者的临床特征、血小板计数和肝功能检查数据。
结果
在总共的样本中，有 415 例（21%）病例被检测出登革热感染，其中 309 例（74%）为男性，106 例（25%）为女性。在登革热阳性患者中，年龄在 21-40 岁的患者中发病率最高，有 160 例（38%），其次是年龄在 1-20 岁的患者，有 89 例（21%）。100%的登革热患者出现发热，其次是 73%的患者出现头痛和疲劳，70%的患者出现肝功能异常。在实验室检查中，180 例检测到 IgM 抗体，其次是 IgG 抗体 87 例，NS1 抗原 43 例，NS1 抗原与 IgG 和 IgM 抗体联合检测 41 例。在 21、21、22 例登革热病例中分别观察到 NS1 抗原与 IgM 抗体、NS1 抗原与 IgG 抗体以及 IgG 和 IgM 抗体的联合检测。
结论
可以根据描述的临床特征和检测登革热特异性 NS1 抗原以及 IgG 和 IgM 抗体来早期诊断登革热感染。
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