Iqbal Naveed, Afridi Muhammad Abdur Rahman, Ali Zafar, Rafiq Adnan
Naveed Iqbal, FCPS. Department of Medicine, Lady Reading Hospital, Medical Teaching Institution, Peshawar, Khyber Pakhtunkhwa, Pakistan.
Muhammad Abdur Rahman Afridi, FCPS Medicine. Department of Medicine, Lady Reading Hospital, Medical Teaching Institution, Peshawar, Khyber Pakhtunkhwa, Pakistan.
Pak J Med Sci. 2023 Sep-Oct;39(5):1301-1306. doi: 10.12669/pjms.39.5.7275.
To determine the association of different blood groups in patients with Dengue fever and their relationship with the severity of the illness.
A hospital-based descriptive study was conducted in the Dengue Isolation Ward of Lady Reading Hospital Peshawar from March 2020 to September 2020. Patients with Dengue fever were included in the study. The severity of the illness was categorized as "Dengue fever (DF)", "Dengue hemorrhagic fever (DHF)", and "Dengue shock syndrome (DSS)". The patients' blood groups were determined as A, B, AB, and O groups. All the data were recorded and analyzed using SPSS® version 23. Chi-square () and student -test were applied, and a -value of ≤0.05 was considered significant.
Out of 160 patients, 119(74.4%) were males; the patient's mean age was 38.09±15.68 SD, IQR=25 years. Greater proportion (28%) of the young men (up to 40 years) was affected compared to 9% young women. Fever (99%) and body aches (96%) were the most common presentation of DF, complicated by bleeding in 30.6% and shock in 9.4% of the patients. The majority (63.1%) of the patients had DF; 27.5% had DHF, and 9.4% had DSS. Sixty three (39.4%) patients had blood Group-B and 5.6% had Group-AB (=0.97). The proportion of patients with different blood groups and the type/severity of the DF were almost identical except the fact that none of the patient with group AB had DSS. There was significant gender difference of hemoglobin (=0.008, 95%=0.439, 2.844), hematocrit (=0.012, 95%=0.00974, 0.07946); and Alanine Aminotransferase levels (=0.002, 95%=-332.032, -72.233).
Patients with blood Group-B were more frequent and AB was least commonly affected by the Dengue-virus infections. However, no association was found between a particular blood group and disease severity. Greater proportions of the younger men had Dengue infections.
确定登革热患者不同血型之间的关联及其与疾病严重程度的关系。
2020年3月至2020年9月在白沙瓦雷丁夫人医院登革热隔离病房进行了一项基于医院的描述性研究。研究纳入登革热患者。疾病严重程度分为“登革热（DF）”、“登革出血热（DHF）”和“登革休克综合征（DSS）”。患者血型确定为A、B、AB和O型。所有数据均使用SPSS®23版进行记录和分析。应用卡方检验（）和学生t检验，P值≤0.05被认为具有统计学意义。
160例患者中，119例（74.4%）为男性；患者平均年龄为38.09±15.68标准差，四分位间距=25岁。与9%的年轻女性相比，更大比例（28%）的年轻男性（40岁及以下）受到影响。发热（99%）和身体疼痛（96%）是登革热最常见的表现，30.6%的患者出现出血并发症，9.4%的患者出现休克。大多数（63.1%）患者为登革热；27.5%为登革出血热，9.4%为登革休克综合征。63例（39.4%）患者为B型血，5.6%为AB型血（=0.97）。除AB型血患者均无登革休克综合征外，不同血型患者的比例与登革热的类型/严重程度几乎相同。血红蛋白（=0.008，95%=0.439，2.844）、血细胞比容（=0.012，95%=0.00974，0.07946）和丙氨酸转氨酶水平（=0.002，95%=-332.032，-72.233）存在显著性别差异。
B型血患者感染登革病毒更为常见，AB型血患者受影响最少。然而，未发现特定血型与疾病严重程度之间存在关联。年轻男性感染登革热的比例更高。
