Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India.
Phytomedicine. 2018 Nov 15;50:148-156. doi: 10.1016/j.phymed.2017.08.025. Epub 2017 Sep 1.
Since ancient times, potential of plants in research and medicine have found pronounced applications, due to better therapeutic value. To meet the mounting demands for commercial nanoparticles, novel eco-friendly methods of synthesis has led to a remarkable progress via unfolding a green synthesis protocol towards metallic nanoparticles synthesis.
HYPOTHESIS/PURPOSE: This review highlights the biological synthesis of various metallic nanoparticles as safe, cost effective process, where the phytochemicals present in extract such as flavonoid, phenols, terpenoids act as capping, reducing and stabilizing agents. Moreover, due to their nano size, the nanoparticles directly bind to bacterial strains leading to higher antimicrobial activity.
Nano-sized dosage systems have a potential for enhancing the activity and overcoming problems associated with phyto medicines. Hence, synthesis of metallic nanoparticles using various plant extracts, emerge as safe alternative to conventional methods for biomedical applications.
自古以来，植物在研究和医学方面的潜力已经得到了广泛的应用，因为它们具有更好的治疗价值。为了满足商业纳米粒子不断增长的需求，新型环保合成方法通过展开绿色合成方案来合成金属纳米粒子，取得了显著的进展。
假说/目的：本综述强调了各种金属纳米粒子的生物合成作为一种安全、具有成本效益的方法，其中提取物中的植物化学物质，如类黄酮、酚类、萜类，作为帽状、还原和稳定剂。此外，由于它们的纳米尺寸，纳米粒子直接与细菌菌株结合，导致更高的抗菌活性。
纳米级剂量系统有可能提高植物药的活性并克服与之相关的问题。因此，使用各种植物提取物合成金属纳米粒子，为生物医学应用提供了一种安全的替代传统方法。
