Brown J H, Pleuvry B J
Br J Anaesth. 1981 Oct;53(10):1033-7. doi: 10.1093/bja/53.10.1033.
The ability of naloxone to antagonize the respiratory effects of alfentanil, a new short-acting analgesic, was studied in the rabbit. The results were compared with naloxone antagonism of fentanyl. Minute volume and respiratory frequency, and pH, PCO2 and standard bicarbonate of arterialized venous blood were measured. Naloxone was more effective as an antagonist to alfentanil than as an antagonist to fentanyl.
在兔子身上研究了纳洛酮拮抗新型短效镇痛药阿芬太尼呼吸效应的能力。将结果与纳洛酮对芬太尼的拮抗作用进行了比较。测量了每分通气量、呼吸频率以及动脉化静脉血的pH、PCO₂和标准碳酸氢盐。纳洛酮作为阿芬太尼的拮抗剂比作为芬太尼的拮抗剂更有效。
