Department of Nephrology and Clinical Poison Center, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
Chang Gung University College of Medicine, Taoyuan, Taiwan.
Sci Rep. 2018 Nov 22;8(1):17251. doi: 10.1038/s41598-018-35217-6.
Uremic pruritus (UP) is a common symptom in patients undergoing hemodialysis (HD). The pathogenesis of UP is complex. Aluminum (Al) is a common metal and is toxic to patients undergoing HD. Al is also a known human allergen which can induce immune reactions. However, the correlation between Al and UP remains unclear in dialysis patients. A total of 866 patients on maintenance HD were enrolled for analysis. The HD patients with higher serum Al levels had higher a prevalence of UP than those with lower serum Al levels. After adjusting for confounding variables, the serum Al level was significantly associated with UP. Overall, each 10-fold increase in serum Al level was associated with a 5.64-fold increase in the risk of developing UP in these subjects. The results of this cross-sectional study suggest that serum Al level may be associated with the development of UP in patients on maintenance HD.
尿毒症瘙痒（UP）是血液透析（HD）患者的常见症状。UP 的发病机制很复杂。铝（Al）是一种常见的金属，对进行血液透析的患者有毒性。Al 也是一种已知的人类过敏原，可引起免疫反应。然而，在透析患者中，Al 与 UP 之间的相关性尚不清楚。共纳入 866 例维持性 HD 患者进行分析。血清 Al 水平较高的血液透析患者 UP 的患病率高于血清 Al 水平较低的患者。调整混杂变量后，血清 Al 水平与 UP 显著相关。总体而言，在这些患者中，血清 Al 水平每增加 10 倍，UP 的发病风险就会增加 5.64 倍。这项横断面研究的结果表明，血清 Al 水平可能与维持性血液透析患者 UP 的发生有关。
