在阿冯父母与儿童纵向研究队列中对常见感染进行的纵向血清学测量。

Longitudinal serological measures of common infection in the Avon Longitudinal Study of Parents and Children cohort.

作者信息

Mitchell Ruth E, Jones Hannah J, Yolken Robert H, Ford Glen, Jones-Brando Lorraine, Ring Susan M, Groom Alix, FitzGibbon Sophie, Davey Smith George, Timpson Nicholas J

机构信息

Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

出版信息

Wellcome Open Res. 2018 Jul 23;3:49. doi: 10.12688/wellcomeopenres.14565.2. eCollection 2018.

DOI:10.12688/wellcomeopenres.14565.2

PMID:30467552

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6124408/

Abstract

Antibodies against pathogens provide information on exposure to infectious agents and are meaningful measures of past and present infection. Antibodies were measured in the plasma of children that are the offspring in a population-based birth cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC). Plasma was collected during clinics at age 5, 7, 11 and 15 years. The antigens examined include: fungal ( ; protozoan ( and surface antigen 1 of ; herpes viruses (cytomegalovirus, Epstein-Barr virus, herpes simplex virus type 1); common colds (influenza virus subtypes H1N1 and H3N2); other antigens (measles); animal (feline herpes virus, Theiler's virus); bacteria ( ); dietary antigens (bovine casein alpha protein, bovine casein beta protein). Alongside the depth of data available within the ALSPAC cohort, this longitudinal resource will enable the investigation of the association between infections and a wide variety of outcomes.

摘要

针对病原体的抗体可提供有关接触感染因子的信息，是衡量过去和当前感染情况的重要指标。我们在基于人群的出生队列“埃文亲子纵向研究”（ALSPAC）中的儿童血浆中检测了抗体。血浆样本在儿童5岁、7岁、11岁和15岁时的门诊期间采集。检测的抗原包括：真菌（）；原生动物（和的表面抗原1）；疱疹病毒（巨细胞病毒、爱泼斯坦-巴尔病毒、1型单纯疱疹病毒）；普通感冒（甲型流感病毒H1N1和H3N2亚型）；其他抗原（麻疹）；动物源性（猫疱疹病毒、泰勒氏病毒）；细菌（）；饮食抗原（α-酪蛋白、β-酪蛋白）。除了ALSPAC队列中丰富的数据深度外，这一纵向资源将有助于研究感染与多种结局之间的关联。