Department of Psychology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL, 60064, USA.
Centers for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, RI, USA.
J Behav Med. 2019 Jun;42(3):522-533. doi: 10.1007/s10865-018-9993-9. Epub 2018 Nov 22.
Behavioral activation is an empirically supported treatment for depression, but much is unknown about factors associated with treatment response. The present study aimed to determine whether baseline levels and subsequent changes in psychosocial factors were associated with improvement in depression in women with comorbid obesity who received behavioral activation treatment for depression and a lifestyle intervention. Multilevel modeling was used to estimate the associations between psychosocial factors and change in depression scores during the first 10 weeks of treatment and associations between changes in psychosocial factors from baseline to 6-month follow-up and change in depression over the same time period. No baseline psychosocial factors were associated with depression improvement during treatment (p = 0.110-0.613). However, greater improvement in hedonic capacity (p = 0.001), environmental reward (p = 0.004), and social impairment (p = 0.012) were associated with greater reductions in depression over 6 months. Findings highlight the differential relationship specific psychosocial factors have with depression treatment outcomes.
行为激活是一种经过实证支持的抑郁症治疗方法，但对于与治疗反应相关的因素知之甚少。本研究旨在确定在接受行为激活治疗抑郁症和生活方式干预的合并肥胖女性中，基线水平和随后的心理社会因素变化是否与抑郁改善相关。采用多层次模型来估计在治疗的前 10 周期间心理社会因素与抑郁评分变化之间的关联，以及从基线到 6 个月随访期间心理社会因素变化与同一时间段内抑郁变化之间的关联。没有基线心理社会因素与治疗期间的抑郁改善相关（p=0.110-0.613）。然而，愉悦能力（p=0.001）、环境奖励（p=0.004）和社会障碍（p=0.012）的较大改善与 6 个月内抑郁的较大降低相关。研究结果强调了特定心理社会因素与抑郁症治疗结果的不同关系。
