浆细胞异常增殖性疾病：现状

Plasma cell dyscrasias: current status.

作者信息

Kyle R A, Greipp P A

机构信息

Mayo Medical School, Mayo Clinic, Rochester, Minnesota.

出版信息

Crit Rev Oncol Hematol. 1988;8(2):93-152. doi: 10.1016/s1040-8428(88)80008-8.

DOI:10.1016/s1040-8428(88)80008-8

PMID:3046767

Abstract

This is a review of the current status of the monoclonal gammopathies (plasma cell dyscrasias). We begin with the recognition of a monoclonal protein in serum and urine. We briefly discuss the differential diagnosis of the monoclonal gammopathies. Clinical and laboratory findings as well as the management of multiple myeloma are addressed. Future approaches for the treatment of myeloma are provided. The variant forms of multiple myeloma, including smoldering myeloma, plasma cell leukemia, nonsecretory myeloma, IgD myeloma, osteosclerotic myeloma, solitary plasmacytoma of bone, and extramedullary plasmacytoma, are briefly reviewed. Diagnosis and treatment of Waldenström's macroglobulinemia are presented. The recognition and differential diagnosis of the heavy-chain diseases (gamma, alpha, and mu) are included. Monoclonal gammopathy of undetermined significance ("benign" monoclonal gammopathy) is presented in detail. Amyloidosis is not included in this review.

摘要

本文是对单克隆丙种球蛋白病（浆细胞发育异常）现状的综述。我们从血清和尿液中识别单克隆蛋白开始。简要讨论单克隆丙种球蛋白病的鉴别诊断。阐述了多发性骨髓瘤的临床和实验室检查结果以及治疗方法。介绍了骨髓瘤未来的治疗方法。简要回顾了多发性骨髓瘤的变异形式，包括冒烟型骨髓瘤、浆细胞白血病、非分泌型骨髓瘤、IgD骨髓瘤、骨硬化性骨髓瘤、孤立性骨浆细胞瘤和髓外浆细胞瘤。介绍了华氏巨球蛋白血症的诊断和治疗。包括重链病（γ、α和μ）的识别和鉴别诊断。详细介绍意义未明的单克隆丙种球蛋白病（“良性”单克隆丙种球蛋白病）。本综述不包括淀粉样变性。