Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, 190011, India.
Department of General and Minimal Invasive Surgery, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, 190011, India.
Pathol Oncol Res. 2020 Jan;26(1):507-513. doi: 10.1007/s12253-018-0540-3. Epub 2018 Nov 22.
Rearranged during transfection (RET) is a proto oncogene implicated in thyroid carcinogenesis of papillary type (PTC). The RET proto-oncogene in PTC is constitutively activated by fusion of its tyrosine kinase domain with the 5 ´region of another gene thereby generating chimeric products collectively named RET/PTCs. RET/PTC1 and RET/PTC3 are best characterized among all RET/PTC rearrangements. Kashmir valley has witnessed an alarming increase in thyroid cancer incidence in young women. Therefore, we investigated the occurrence of RET/PTC 1 & 3 rearrangements by semi quantitative and qPCR in thyroid cancer patients (n = 48) of Kashmiri population and interrelated results with various clinicopathological characteristics. We observed that all the RET/PTC rearrangements were confined to PTC cases (10/40). Presence of RET/PTC rearrangement significantly correlated with gender, elevated TSH levels and lymph node metastasis. Overall, our study advocates that RET/PTC3 rearrangement is a frequent event in the carcinogenesis of thyroid gland in Kashmiri population although a study with a larger sample size is needed to get a clear scenario.
重排在转染时 (RET) 是一个原癌基因参与甲状腺癌的乳头状类型 (PTC)。在 PTC 的 RET 原癌基因通过融合其酪氨酸激酶结构域与另一个基因的 5 ´区域被组成性激活，从而产生统称为 RET/PTCs 的嵌合产物。在所有的 RET/PTC 重排中，RET/PTC1 和 RET/PTC3 是最好的特征。克什米尔河谷见证了年轻女性甲状腺癌发病率的惊人增长。因此，我们通过半定量和 qPCR 在克什米尔人群的甲状腺癌患者 (n = 48) 中调查了 RET/PTC1 和 3 重排的发生，并与各种临床病理特征的相关结果进行了研究。我们观察到所有的 RET/PTC 重排都局限于 PTC 病例 (10/40)。RET/PTC 重排的存在与性别、升高的 TSH 水平和淋巴结转移显著相关。总的来说，我们的研究表明，RET/PTC3 重排在克什米尔人群甲状腺癌的发生中是一个频繁的事件，尽管需要更大的样本量来获得更清晰的情况。
