心肺适能对青年人群心血管疾病多种风险因素聚集的影响及体重指数的中介作用：UP&DOWN 研究。
The influence of cardiorespiratory fitness on clustered cardiovascular disease risk factors and the mediator role of body mass index in youth: The UP&DOWN Study.
机构信息
Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Puerto Real, Spain.
Center for Cognitive and Brain Health, Department of Psychology, Northeastern University, Boston, MA, USA.
出版信息
Pediatr Diabetes. 2019 Feb;20(1):32-40. doi: 10.1111/pedi.12800. Epub 2018 Dec 10.
BACKGROUND
The combined effect of cardiorespiratory fitness (CRF) and body mass index (BMI) on cardiovascular disease (CVD) risk in young people remains to be fully determined. We examined the individual and combined associations of CRF and BMI with clustered CVD risk factors, and the mediator role of BMI in the association between CRF and clustered CVD risk factors in children and adolescents.
METHODS
237 children (111 girls) and 260 adolescents (120 girls) were included in this cross-sectional study. Height and weight were assessed and BMI was calculated. A CVD risk factor index (CVDRF-I) was computed from: waist circumference, systolic blood pressure, triglycerides, high-density lipoprotein cholesterol and glucose. CRF was assessed using the 20-m shuttle run test. Regression analysis, analysis of covariance and mediation analysis (Baron and Kenny procedures) were used to test the independent and combined effect of CRF and BMI on CVDRF-I, and to test mediation hypothesis, respectively.
RESULTS
CRF was negatively associated with CVDRF-I (all P < 0.05); however, after adjusting for BMI the associations were no longer significant in children and adolescents of both sex groups. Contrary, the association between BMI and CVDRF-I was independent of CRF (all P < 0.001). The effect of CRF on CVDRF-I was mediated by BMI. The percentage of the total effect of CRF on CVDRF-I mediated by BMI for boys and girls children and boys and girls adolescents were 79.5%, 100%, 81.2% and 55.7%, respectively.
CONCLUSIONS
BMI is an independent predictor of CVDRF-I and a mediator of the association between CRF and CVDRF-I in children and adolescents. These results help to clarify the associations between CRF, weight status and cardiovascular health, suggesting that future CVD health would benefit from maintaining an optimal weight status.
背景
心肺适能（CRF）和体重指数（BMI）对年轻人心血管疾病（CVD）风险的综合影响仍有待充分确定。我们研究了 CRF 和 BMI 与 CVD 风险因素群集的个体和联合关联，以及 BMI 在 CRF 与儿童和青少年 CVD 风险因素群集之间的关联中的中介作用。
方法
本横断面研究纳入了 237 名儿童（111 名女孩）和 260 名青少年（120 名女孩）。评估身高和体重，并计算 BMI。CVD 风险因素指数（CVDRF-I）由腰围、收缩压、甘油三酯、高密度脂蛋白胆固醇和血糖计算得出。CRF 使用 20 米穿梭跑测试进行评估。回归分析、协方差分析和中介分析（Baron 和 Kenny 程序）用于检验 CRF 和 BMI 对 CVDRF-I 的独立和综合作用，并分别检验中介假设。
结果
CRF 与 CVDRF-I 呈负相关（均 P<0.05）；然而，在调整 BMI 后，男女两组儿童和青少年的关联不再显著。相反，BMI 与 CVDRF-I 的关联独立于 CRF（均 P<0.001）。CRF 对 CVDRF-I 的影响由 BMI 介导。BMI 介导 CRF 对 CVDRF-I 总效应的百分比分别为男孩和女孩儿童的 79.5%、100%、男孩和女孩青少年的 81.2%和 55.7%。
结论
BMI 是 CVDRF-I 的独立预测因子，也是 CRF 与 CVDRF-I 之间关联的中介。这些结果有助于澄清 CRF、体重状况与心血管健康之间的关联，表明未来的 CVD 健康将受益于维持最佳体重状况。
Zotero 插件