Pescitelli Leonardo, Ricceri Federica, Prignano Francesca
Unit of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.
Unit of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy -
G Ital Dermatol Venereol. 2018 Jun;153(3 Suppl 2):8-17. doi: 10.23736/S0392-0488.17.05772-8.
Hidradenitis suppurativa is a chronic, inflammatory, recurrent, debilitating skin disease characterized by recurrent abscesses, draining sinuses, and scarring, affecting principally areas of body friction. Although the disease pathogenesis is not fully understood, recent advances suggest that hidradenitis suppurativa should be viewed as a systemic inflammatory disease. Moreover, recent studies have defined hidradenitis suppurativa as a systemic disease linked to several comorbidities. Metabolic disorders including obesity and metabolic syndrome are the most common associated conditions observed in patients with hidradenitis suppurativa. Autoimmune diseases, like inflammatory bowel diseases, autoinflammatory diseases, spondyloarthritis, some genetic keratin disorders and also the risk of skin tumor seems to occur more frequently in these patients. This disease can also have severe effects on self-esteem and quality of life and can be associated with psychiatric diseases. The link between hidradenitis suppurativa and systemic associations may be attributed to common genetic or environmental factors or shared inflammatory pathways. Due to these reasons it is mandatory that clinical intervention for hidradenitis suppurativa must include consideration and attention to these comorbidities and complications. In this article we have reviewed current available literature on diseases that can occur together with hidradenitis suppurativa.
化脓性汗腺炎是一种慢性、炎症性、复发性、使人衰弱的皮肤病，其特征为反复出现脓肿、引流窦道和瘢痕形成，主要累及身体易摩擦部位。尽管该病的发病机制尚未完全明确，但最近的研究进展表明，化脓性汗腺炎应被视为一种全身性炎症性疾病。此外，最近的研究已将化脓性汗腺炎定义为一种与多种合并症相关的全身性疾病。代谢紊乱，包括肥胖和代谢综合征，是化脓性汗腺炎患者中最常见的相关病症。自身免疫性疾病，如炎症性肠病、自身炎症性疾病、脊柱关节炎、一些遗传性角蛋白疾病，以及皮肤肿瘤的风险，似乎在这些患者中更频繁地出现。这种疾病还会对自尊和生活质量产生严重影响，并可能与精神疾病相关。化脓性汗腺炎与全身性关联之间的联系可能归因于共同的遗传或环境因素或共享的炎症途径。由于这些原因，化脓性汗腺炎的临床干预必须包括对这些合并症和并发症的考虑和关注。在本文中，我们综述了目前关于可与化脓性汗腺炎同时发生的疾病的现有文献。
