Department of Clinical Pharmacology, Xiangya Hospital, Central South University and Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410008, PR China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, PR China.
Key Laboratory of Translational Radiation Oncology, Hunan Province, Department of Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, PR China.
Gene. 2019 Mar 1;687:219-227. doi: 10.1016/j.gene.2018.11.061. Epub 2018 Nov 20.
Jab1/CSN5 is a conserved multifunctional protein involved in ubiquitin-mediated protein degradation. Deregulation of Jab1/CSN5 can exert dramatic effects on diverse cellular functions, including DNA repair, cell cycle control, apoptosis, angiogenesis, and signal transduction, all of which are critical for tumor development. Although increasing evidence has demonstrated that Jab1/CSN5 was overexpressed in a variety of human cancers and usually correlated with poor prognosis, little was known about the underlying regulatory principles that coordinated its function. In this review, we highlight recent advances of the oncogenic role of Jab1/CSN5 and its potential as a therapeutic target for anticancer intervention.
Jab1/CSN5 是一种保守的多功能蛋白，参与泛素介导的蛋白质降解。Jab1/CSN5 的失调会对多种细胞功能产生巨大影响，包括 DNA 修复、细胞周期控制、细胞凋亡、血管生成和信号转导，所有这些对肿瘤的发展都至关重要。尽管越来越多的证据表明 Jab1/CSN5 在多种人类癌症中过表达，通常与预后不良相关，但关于协调其功能的潜在调节原则知之甚少。在这篇综述中，我们强调了 Jab1/CSN5 的致癌作用及其作为抗癌干预治疗靶点的潜力的最新进展。
