针对鼻咽癌中的 Jab1/CSN5。
Targeting Jab1/CSN5 in nasopharyngeal carcinoma.
机构信息
Department of Systems Biology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
出版信息
Cancer Lett. 2012 Dec 30;326(2):155-60. doi: 10.1016/j.canlet.2012.07.033. Epub 2012 Aug 4.
Abstract
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus-associated head and neck cancer that is most common in eastern Asia. Epstein-Barr virus infection, environmental factors, and genetic susceptibility play important roles in NPC pathogenesis. Jab1/CSN5 is a multifunctional protein that participates in affecting integrin signaling, controlling cell proliferation and apoptosis, and regulating genomic instability and DNA repair. Correlation of Jab1/CSN5 overexpression with poor prognosis for NPC provides evidence that it is involved in the tumorigenic process. In this review, we highlight recent advances in studies of the oncogenic role of Jab1/CSN5 in NPC and its potential as a therapeutic target for this cancer.
摘要
鼻咽癌（NPC）是一种与 Epstein-Barr 病毒相关的头颈部癌症，在东亚地区最为常见。Epstein-Barr 病毒感染、环境因素和遗传易感性在 NPC 的发病机制中发挥着重要作用。Jab1/CSN5 是一种多功能蛋白，参与影响整合素信号转导、控制细胞增殖和凋亡、调节基因组不稳定性和 DNA 修复。Jab1/CSN5 过表达与 NPC 预后不良相关，这为其参与肿瘤发生过程提供了证据。在这篇综述中，我们重点介绍了 Jab1/CSN5 在 NPC 中的致癌作用及其作为该癌症治疗靶点的潜力的最新研究进展。
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本文引用的文献
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2
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