King Abdullah University of Science and Technology (KAUST), Biological and Environmental Science and Engineering (BESE), 23955-6900 Thuwal, Saudi Arabia.
King Abdullah University of Science and Technology (KAUST), Biological and Environmental Science and Engineering (BESE), 23955-6900 Thuwal, Saudi Arabia.
J Inorg Biochem. 2019 Feb;191:69-76. doi: 10.1016/j.jinorgbio.2018.11.004. Epub 2018 Nov 10.
Islet Amyloid Polypeptide (IAPP), also known as amylin, is a 37-amino-acid peptide hormone that is secreted by pancreatic islet β-cells. Amylin is complementary to insulin in regulating and maintaining blood glucose levels in the human body. The misfolding and aggregation of amylin is primarily associated with type 2 diabetes mellitus, which is classified as an amyloid disease. Recently, the interactions between amylin and specific metal ions, e.g., copper(II), zinc(II), and iron(II), were found to impact its performance and aggregation processes. Therefore, the focus in this review will be on how the chemistry and structural properties of amylin are affected by these interactions. In addition, the impact of amylin and other amyloidogenic peptides interacting with metal ions on the cell membranes is discussed. In particular, recent studies on the interactions of amylin with copper, zinc, iron, nickel, gold, ruthenium, and vanadium are discussed.
胰岛淀粉样多肽（IAPP），也称为胰岛淀粉样肽，是一种由胰岛β细胞分泌的 37 个氨基酸的激素。胰岛淀粉样肽与胰岛素互补，共同调节和维持人体的血糖水平。胰岛淀粉样肽的错误折叠和聚集主要与 2 型糖尿病有关，2 型糖尿病被归类为淀粉样变性疾病。最近，人们发现胰岛淀粉样肽与特定金属离子（如铜（II）、锌（II）和铁（II））之间的相互作用会影响其性能和聚集过程。因此，本综述的重点将放在这些相互作用如何影响胰岛淀粉样肽的化学和结构性质上。此外，还讨论了胰岛淀粉样肽和其他淀粉样肽与金属离子相互作用对细胞膜的影响。特别讨论了最近关于胰岛淀粉样肽与铜、锌、铁、镍、金、钌和钒相互作用的研究。
