School of Public Health, Dalian Medical University, Dalian, Liaoning, People's Republic of China.
Department of Nutrition and Food Hygiene, Global Health Research Center, School of Public Health, Dalian Medical University, Dalian, Liaoning, People's Republic of China.
Mol Med. 2022 Nov 5;28(1):130. doi: 10.1186/s10020-022-00558-6.
Obesity is one of the major public health problems threatening the world, as well as a potential risk factor for chronic metabolic diseases. There is growing evidence that iron metabolism is altered in obese people, however, the highly refined regulation of iron metabolism in obesity and obesity-related complications is still being investigated. Iron accumulation can affect the body's sensitivity to insulin, Type 2 diabetes, liver disease and cardiovascular disease. This review summarized the changes and potential mechanisms of iron metabolism in several chronic diseases related to obesity, providing new clues for future research.
肥胖是威胁世界的主要公共卫生问题之一,也是慢性代谢性疾病的潜在危险因素。越来越多的证据表明,肥胖人群的铁代谢发生了改变,然而,肥胖及其相关并发症中铁代谢的高度精细化调节仍在研究之中。铁的积累会影响身体对胰岛素的敏感性,导致 2 型糖尿病、肝脏疾病和心血管疾病。本综述总结了肥胖相关的几种慢性疾病中铁代谢的变化和潜在机制,为未来的研究提供了新的线索。