Department of Obstetrics and Gynecology, The First Hospital of Lanzhou University, Lanzhou 730000, China.
Department of Plastic Surgery, The Gansu Provincial Hospital, Lanzhou 730000, China.
Biomed Pharmacother. 2019 Feb;110:139-144. doi: 10.1016/j.biopha.2018.11.020. Epub 2018 Nov 20.
Nectin-3 is a cell adhesion molecule that functions in tight junctions. Recent reports have implicated nectin-3 in pancreatic adenocarcinoma and lung adenocarcinoma. However, there has been little exploration of the expression, cellular invasion and migration of nectin-3 in ovarian cancer (OC). We evaluated the distribution of cells that were positive for nectin-3 using immunohistochemistry in specimens of human OC and correlated these results with overall survival (OS). The nectin-3 expression was significantly increased accompanied by a degree of malignancy in ovarian tumors; moreover, the expression of matrix metallopeptidases (MMP) 2 and 9 was upregulated. In addition, an increased level of nectin-3 was related to a poorer OS. In summary, we have demonstrated that cellular migration and invasion via nectin-3 mediate the upregulation of MMP2 and MMP9 in OC cells. Nectin-3 may be a new biomarker for OC diagnosis.
黏附分子 3 是一种细胞黏附分子，在紧密连接中发挥作用。最近的报告表明黏附分子 3 与胰腺腺癌和肺腺癌有关。然而，关于黏附分子 3 在卵巢癌 (OC) 中的表达、细胞侵袭和迁移的研究较少。我们使用免疫组织化学评估了人类 OC 标本中黏附分子 3 阳性细胞的分布，并将这些结果与总生存 (OS) 相关联。黏附分子 3 的表达随着卵巢肿瘤恶性程度的增加而显著增加；此外，基质金属蛋白酶 (MMP) 2 和 9 的表达也上调。此外，黏附分子 3 水平的升高与较差的 OS 相关。综上所述，我们已经证明，通过黏附分子 3 介导的细胞迁移和侵袭，调节 OC 细胞中 MMP2 和 MMP9 的表达。黏附分子 3 可能是 OC 诊断的一个新的生物标志物。
